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ZIRC
ZFIN ID: ZDB-GENE-030131-5607
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Gene Name: Ras-related associated with diabetes
Gene Symbol: rrad    Nomenclature History

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Previous Names: fi06a10, wu:fi06a10, zgc:63471

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Exhibits calcium channel regulator activity. Predicted to be involved in negative regulation of high voltage-gated calcium channel activity and signal transduction. Predicted to localize to the plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in cardiovascular system; endocrine system; nervous system; and otic vesicle. Orthologous to human RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator).
Genome Resources: Alliance (1),  Gene:327396 (1),  Ensembl(GRCz11):ENSDARG00000052011 (1)
GENE EXPRESSION
All Expression Data: 8 figures from 2 publications
Directly Submitted Expression Data: 7 figures (15 images) from Thisse et al., 2004 [MGC:63471]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1939 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH rrad HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH rrad VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of high voltage-gated calcium channel activity (more)
    Cellular Component membrane (more)
    Molecular Function calcium channel regulator activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001806 (1)
  • InterPro:IPR005225 (1)
  • InterPro:IPR017358 (1)
  • InterPro:IPR020849 (1)
  • InterPro:IPR027417 (1)
  • InterPro:IPR028869 (1)
  • PROSITE:PS51421 (1)
  • Pfam:PF00071 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rrad-201 (1)    Ensembl 1747
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rrad No data available
    MARKER RELATIONSHIPS
    rrad Contained in: [BAC] CH211-235L10 (1) (order this)
    rrad Encodes: [EST] fi06a10
    [cDNA] MGC:63471 (1) (order this), MGC:174042 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199798 (1) 1778 bp
    Select Tool
    Genomic GenBank:BX511110 (1) 89482 bp
    Select Tool
    Polypeptide UniProtKB:A8E566 (1) 300 aa
    Select Tool
    Sequence Clusters UniGene:80392 (1)
    Sequence Information (all 22)
    ORTHOLOGY for rrad ( Chr: 7 )
    CITATIONS (22)