Gene
ndrg3b
- ID
- ZDB-GENE-030131-5606
- Name
- ndrg family member 3b
- Symbol
- ndrg3b Nomenclature History
- Previous Names
-
- fi05h10
- wu:fi05h10
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Is expressed in immature eye; nervous system; otic vesicle; pectoral fin bud; and thymus. Orthologous to human NDRG3 (NDRG family member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55301 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Li et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la022474Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa10361 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18512 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24278 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa25194 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32432 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha/Beta hydrolase fold | NDRG |
|---|---|---|---|---|
| UniProtKB:A0A8M3AY71 | InterPro | 376 | ||
| UniProtKB:Q803Y9 | InterPro | 371 | ||
| UniProtKB:A0A8M3ANG1 | InterPro | 384 | ||
| UniProtKB:A0A8M3AV52 | InterPro | 390 | ||
| UniProtKB:F1Q947 | InterPro | 371 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ndrg3b-201
(1)
|
Ensembl | 2,350 nt | ||
| mRNA |
ndrg3b-208
(1)
|
Ensembl | 600 nt | ||
| mRNA |
ndrg3b-209
(1)
|
Ensembl | 5,336 nt | ||
| ncRNA |
ndrg3b-003
(1)
|
Ensembl | 499 nt | ||
| ncRNA |
ndrg3b-004
(1)
|
Ensembl | 878 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218G4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-3A9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-78O15 | ZFIN Curated Data | |
| Encodes | EST | fi05h10 | ||
| Encodes | cDNA | MGC:55301 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199797 (1) | 2361 nt | ||
| Genomic | GenBank:CR318666 (1) | 198176 nt | ||
| Polypeptide | UniProtKB:A0A8M3AV52 (1) | 390 aa |
- Park, J.S., Gabel, A.M., Kassir, P., Kang, L., Chowdhary, P.K., Osei-Ntansah, A., Tran, N.D., Viswanathan, S., Canales, B., Ding, P., Lee, Y.S., Brewster, R. (2022) N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia. eLIFE. 11:
- Le, N., Hufford, T.M., Park, J.S., Brewster, R.M. (2021) Differential expression and hypoxia-mediated regulation of the N-myc downstream regulated gene family. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35:e21961
- Yan, Y.L., Batzel, P., Titus, T., Sydes, J., Desvignes, T., Bremiller, R., Draper, B., Postlethwait, J.H. (2019) A Hormone That Lost Its Receptor: Anti-Müllerian Hormone (AMH) in Zebrafish Gonad Development and Sex Determination. Genetics. 213(2):529-553
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Takeuchi, M., Yamaguchi, S., Sakakibara, M., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., Hibi, M. (2017) Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. The Journal of comparative neurology. 525(7):1558-1585
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Li, R.A., Traver, D., Matthes, T., Bertrand, J.Y. (2016) Ndrg1b and fam49ab modulate the PTEN pathway to control T cell lymphopoiesis in the zebrafish. Blood. 128(26):3052-3060
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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