ZFIN ID: ZDB-GENE-030131-556
Gene Name: kelch-like ECH-associated protein 1a
Gene Symbol: keap1a    Nomenclature History

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Previous Names: keap1, klhl19 (1), wu:fb36f11 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Involved in cellular protein metabolic process; cellular response to prostaglandin stimulus; and cellular response to xenobiotic stimulus. Predicted to localize to cytoplasm and inclusion body. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1).
Genome Resources: Alliance (1),  Gene:321837 (1),  Ensembl(GRCz11):ENSDARG00000016132 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12803 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH keap1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH keap1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to prostaglandin stimulus (more)
    Cellular Component cytoplasm (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA keap1a-201 (1)    Ensembl 2868
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM keap1a No data available
    MARKER RELATIONSHIPS
    keap1a Contained in: [BAC] CH211-107E10 (1), DKEY-97A13 (1) (order this)
    keap1a Encodes: [EST] fb36f11
    [cDNA] MGC:136521 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_182864 (1) 2888 nt
    Genomic GenBank:BX663525 (1) 261927 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q1ECZ2 (1) 601 aa
    Sequence Information (all 15)
    ORTHOLOGY for keap1a ( Chr: 2 )
    CITATIONS (57)