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Gene

sec23b

ID
ZDB-GENE-030131-5479
Name
SEC23 homolog B, coat complex II component
Symbol
sec23b Nomenclature History
Previous Names
  • fl08h02
  • wu:fd19h01
  • wu:fl08h02
  • zgc:55595
  • zgc:86871
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable GTPase activator activity. Acts upstream of or within cartilage development; embryonic neurocranium morphogenesis; and erythrocyte development. Predicted to be located in cytoplasmic vesicle; cytosol; and endoplasmic reticulum membrane. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Human ortholog(s) of this gene implicated in Cowden syndrome and congenital dyserythropoietic anemia type II. Orthologous to human SEC23B (SEC23 homolog B, COPII coat complex component).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sec23b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital dyserythropoietic anemia type II Alliance Dyserythropoietic anemia, congenital, type II 224100
Cowden syndrome 7 Alliance ?Cowden syndrome 7 616858
Associated With sec23b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006895 Zinc finger, Sec23/Sec24-type
Domain IPR006896 Sec23/Sec24, trunk domain
Domain IPR006900 Sec23/Sec24, helical domain
Domain IPR007123 Gelsolin-like domain
Domain IPR012990 Sec23/Sec24 beta-sandwich
Domain IPR037550 Sec23, C-terminal
Family IPR037364 Protein transport protein Sec23
Homologous_superfamily IPR029006 ADF-H/Gelsolin-like domain superfamily
Homologous_superfamily IPR036174 Zinc finger, Sec23/Sec24-type superfamily
Homologous_superfamily IPR036175 Sec23/Sec24 helical domain superfamily
Homologous_superfamily IPR036180 Gelsolin-like domain superfamily
Homologous_superfamily IPR036465 von Willebrand factor A-like domain superfamily
Domain Details Per Protein
Protein Length ADF-H/Gelsolin-like domain superfamily Gelsolin-like domain Gelsolin-like domain superfamily Protein transport protein Sec23 Sec23, C-terminal Sec23/Sec24 beta-sandwich Sec23/Sec24, helical domain Sec23/Sec24 helical domain superfamily Sec23/Sec24, trunk domain von Willebrand factor A-like domain superfamily Zinc finger, Sec23/Sec24-type Zinc finger, Sec23/Sec24-type superfamily
UniProtKB:Q7ZVV7 766
UniProtKB:F1R7W8 754
UniProtKB:Q6TNV9 767
UniProtKB:Q6AZ98 766
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations