Gene
hdac10
- ID
- ZDB-GENE-030131-5464
- Name
- histone deacetylase 10
- Symbol
- hdac10 Nomenclature History
- Previous Names
-
- wu:fd19e10
- zgc:55652 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Enables acetylspermidine deacetylase activity and zinc ion binding activity. Acts upstream of or within regulation of tubulin deacetylation; spermidine deacetylation; and swimming behavior. Predicted to be located in cytoplasm. Orthologous to human HDAC10 (histone deacetylase 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55652 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sh401 | Allele with one deletion | Exon 4 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hdac10 | Łysyganicz et al., 2021 | |
| CRISPR2-hdac10 | Saraswathy et al., 2024 | |
| MO1-hdac10 | N/A | Huang et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR023801 | Histone deacetylase domain |
| Family | IPR000286 | Histone deacetylase family |
| Family | IPR050284 | Histone deacetylase and polyamine deacetylase |
| Homologous_superfamily | IPR023696 | Ureohydrolase domain superfamily |
| Homologous_superfamily | IPR037138 | Histone deacetylase domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Histone deacetylase and polyamine deacetylase | Histone deacetylase domain | Histone deacetylase domain superfamily | Histone deacetylase family | Ureohydrolase domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PY99 | InterPro | 723 | |||||
| UniProtKB:F1QCV2 | InterPro PDB | 675 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hdac10-201
(1)
|
Ensembl | 2,287 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-265H17 | ZFIN Curated Data | |
| Contains | SNP | rs3729360 | ZFIN Curated Data | |
| Contains | SNP | rs3729361 | ZFIN Curated Data | |
| Contains | SNP | rs3729362 | ZFIN Curated Data | |
| Contains | SNP | rs3729363 | ZFIN Curated Data | |
| Contains | SNP | rs3729364 | ZFIN Curated Data | |
| Contains | SNP | rs3729365 | ZFIN Curated Data | |
| Encodes | EST | fd19e10 | ||
| Encodes | cDNA | MGC:55652 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199775 (1) | 2282 nt | ||
| Genomic | GenBank:FP102808 (1) | 108142 nt | ||
| Polypeptide | UniProtKB:A0A8M9PY99 (1) | 723 aa |
- Saraswathy, V.M., Zhou, L., Mokalled, M.H. (2024) Single-cell analysis of innate spinal cord regeneration identifies intersecting modes of neuronal repair. Nature communications. 15:68086808
- Rozenblat, R., Tovin, A., Zada, D., Lebenthal-Loinger, I., Lerer-Goldshtein, T., Appelbaum, L. (2022) Genetic and Neurological Deficiencies in the Visual System of mct8 Mutant Zebrafish. International Journal of Molecular Sciences. 23(5):
- Herbst-Gervasoni, C.J., Christianson, D.W. (2021) X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10. Biochemistry. 60:303-313
- Łysyganicz, P.K., Pooranachandran, N., Liu, X., Adamson, K.I., Zielonka, K., Elworthy, S., van Eeden, F.J., Grierson, A.J., Malicki, J.J. (2021) Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia. Frontiers in cell and developmental biology. 9:676214
- Herbst-Gervasoni, C.J., Steimbach, R.R., Morgen, M., Miller, A.K., Christianson, D.W. (2020) Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase. ACS Chemical Biology. 15(8):2154-2163
- Fellous, A., Earley, R.L., Silvestre, F. (2019) Identification and expression of mangrove rivulus (Kryptolebias marmoratus) histone deacetylase (Hdac) and lysine acetyltransferase (Kat) genes. Gene. 691:56-69
- Herbst-Gervasoni, C.J., Christianson, D.W. (2019) Binding of N8-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation. Biochemistry. 58(49):4957-4969
- Mitra, S., Sharma, P., Kaur, S., Khursheed, M.A., Gupta, S., Ahuja, R., Kurup, A.J., Chaudhary, M., Ramachandran, R. (2018) Histone Deacetylase-Mediated Müller Glia Reprogramming through Her4.1-Lin28a Axis Is Essential for Retina Regeneration in Zebrafish. iScience. 7:68-84
- Zhang, J., Zhou, Y., Wu, C., Wan, Y., Fang, C., Li, J., Fang, W., Yi, R., Zhu, G., Li, J., Wang, Y. (2018) Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Frontiers in endocrinology. 9:756
- Hai, Y., Shinsky, S.A., Porter, N.J., Christianson, D.W. (2017) Histone deacetylase 10 structure and molecular function as a polyamine deacetylase. Nature communications. 8:15368
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