Gene
eif2b5
- ID
- ZDB-GENE-030131-5364
- Name
- eukaryotic translation initiation factor 2B, subunit 5 epsilon
- Symbol
- eif2b5 Nomenclature History
- Previous Names
-
- fd14g07
- wu:fd14g07
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity; translation initiation factor activity; and translation initiation factor binding activity. Predicted to act upstream of or within translational initiation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in brain; eye; myotome; optic vesicle; and pharyngeal arch. Used to study leukoencephalopathy with vanishing white matter. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter and leukoencephalopathy with vanishing white matter 5. Orthologous to human EIF2B5 (eukaryotic translation initiation factor 2B subunit epsilon).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7150951 (13 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| leukoencephalopathy with vanishing white matter 5 | Alliance | Leukoencephalopathy with vanishing white matter 5, with or without ovarian failure | 620315 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| leukoencephalopathy with vanishing white matter | eif2b5zc102/zc102 | standard conditions | Keefe et al., 2020 |
| leukoencephalopathy with vanishing white matter | eif2b5zc103/zc103 | standard conditions | (2) |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003307 | W2 domain |
| Domain | IPR005835 | Nucleotidyl transferase domain |
| Domain | IPR035543 | Translation initiation factor eIF-2B subunit epsilon, N-terminal |
| Domain | IPR044123 | Translation initiation factor eIF-2B subunit epsilon, W2 domain |
| Family | IPR051956 | eIF2B Complex Subunit Epsilon |
| Homologous_superfamily | IPR011004 | Trimeric LpxA-like superfamily |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR029044 | Nucleotide-diphospho-sugar transferases |
| Repeat | IPR001451 | Hexapeptide repeat |
Domain Details Per Protein
| Protein | Length | Armadillo-type fold | eIF2B Complex Subunit Epsilon | Hexapeptide repeat | Nucleotide-diphospho-sugar transferases | Nucleotidyl transferase domain | Translation initiation factor eIF-2B subunit epsilon, N-terminal | Translation initiation factor eIF-2B subunit epsilon, W2 domain | Trimeric LpxA-like superfamily | W2 domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A8WG65
|
703 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
eif2b5-201
(1)
|
Ensembl | 1,832 nt |
Interactions and Pathways
No data available
Plasmids
No data available