Gene

hyou1

ID

ZDB-GENE-030131-5344

Name

hypoxia up-regulated 1

Symbol

hyou1 Nomenclature History

Previous Names

id:ibd5056
wu:fd14c05
zgc:56019

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have ATP binding activity. Predicted to be involved in cellular response to hypoxia and negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway. Predicted to localize to endoplasmic reticulum chaperone complex. Is expressed in several structures, including anterior axial hypoblast; digestive system; hatching gland; immature eye; and polster. Orthologous to human HYOU1 (hypoxia up-regulated 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7141613 (3 images)
IMAGE:6895638 (5 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hyou1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency 59	Alliance	?Immunodeficiency 59 and hypoglycemia	233600

Associated With hyou1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018181	Heat shock protein 70, conserved site
Family	IPR013126	Heat shock protein 70 family
Homologous_superfamily	IPR029047	Heat shock protein 70kD, peptide-binding domain superfamily
Homologous_superfamily	IPR029048	Heat shock protein 70kD, C-terminal domain superfamily
Homologous_superfamily	IPR043129	ATPase, nucleotide binding domain

Domain Details Per Protein

Protein	Length	ATPase, nucleotide binding domain	Heat shock protein 70, conserved site	Heat shock protein 70 family	Heat shock protein 70kD, C-terminal domain superfamily	Heat shock protein 70kD, peptide-binding domain superfamily
UniProtKB:Q7ZUW2 InterPro	980
UniProtKB:B2GRZ4 InterPro	980

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	hyou1-201 (1) Ensembl	Ensembl	3,959 nt	Select Tool ZFIN BLAST
mRNA	hyou1-203 (1) Ensembl	Ensembl	2,951 nt	Select Tool ZFIN BLAST
mRNA	hyou1-204 (1) Ensembl	Ensembl	3,965 nt	Select Tool ZFIN BLAST
ncRNA	hyou1-002 (1) Ensembl	Ensembl	734 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations