Gene
rpl12
- ID
- ZDB-GENE-030131-5297
- Name
- ribosomal protein L12
- Symbol
- rpl12 Nomenclature History
- Previous Names
-
- wu:fa27c04
- wu:fa91d03
- wu:fb14g09
- wu:fj26g11
- zgc:103615
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have large ribosomal subunit rRNA binding activity. Predicted to be involved in ribosomal large subunit assembly and translation. Predicted to localize to cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Is expressed in endodermal cell; eye; intestine; liver; and pancreas. Orthologous to human RPL12 (ribosomal protein L12).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56662 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
hi3076Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
la024985Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa26510 | Allele with one point mutation | Unknown | Unknown | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR020785 | Large ribosomal subunit protein uL11, conserved site |
Domain | IPR020783 | Large ribosomal subunit protein uL11, C-terminal |
Domain | IPR020784 | Large ribosomal subunit protein uL11, N-terminal |
Family | IPR000911 | Ribosomal protein uL11 |
Homologous_superfamily | IPR036769 | Large ribosomal subunit protein uL11, C-terminal domain superfamily |
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Domain Details Per Protein
Protein | Length | Large ribosomal subunit protein uL11, conserved site | Large ribosomal subunit protein uL11, C-terminal | Large ribosomal subunit protein uL11, C-terminal domain superfamily | Large ribosomal subunit protein uL11, N-terminal | Large ribosomal subunit protein uL11, N-terminal domain superfamily | Ribosomal protein uL11 |
---|---|---|---|---|---|---|---|
UniProtKB:Q7ZUG1
|
165 | ||||||
UniProtKB:Q6DRE6
|
165 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-208H16 | ZFIN Curated Data | |
Encodes | EST | fa27c04 | ||
Encodes | EST | fa91d03 | ZFIN Curated Data | |
Encodes | EST | fb14g09 | ZFIN Curated Data | |
Encodes | EST | fj26g11 | ||
Encodes | cDNA | MGC:56662 | ZFIN Curated Data | |
Encodes | cDNA | MGC:103615 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192501 | ZFIN Curated Data | |
Is Hybridized by | EST | fj18a12 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_201584 (1) | 660 nt | ||
Genomic | GenBank:CR925757 (1) | 154617 nt | ||
Polypeptide | UniProtKB:Q6DRE6 (1) | 165 aa |
- Li, Y.F., Cheng, T., Zhang, Y.J., Fu, X.X., Mo, J., Zhao, G.Q., Xue, M.G., Zhuo, D.H., Xing, Y.Y., Huang, Y., Sun, X.Z., Wang, D., Liu, X., Dong, Y., Zhu, X.S., He, F., Ma, J., Chen, D., Jin, X., Xu, P.F. (2022) Mycn regulates intestinal development through ribosomal biogenesis in a zebrafish model of Feingold syndrome 1. PLoS Biology. 20:e3001856
- Ayobahan, S.U., Eilebrecht, E., Kotthoff, M., Baumann, L., Eilebrecht, S., Teigeler, M., Hollert, H., Kalkhof, S., Schäfers, C. (2019) A combined FSTRA-shotgun proteomics approach to identify molecular changes in zebrafish upon chemical exposure. Scientific Reports. 9:6599
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Zhang, Y., O'Leary, M.N., Peri, S., Wang, M., Zha, J., Melov, S., Kappes, D.J., Feng, Q., Rhodes, J., Amieux, P.S., Morris, D.R., Kennedy, B.K., Wiest, D.L. (2017) Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing. Cell Reports. 18:545-556
- Cai, Y., Zhang, C., Hao, L., Chen, J., Xie, P., Chen, Z. (2016) Systematic identification of seven ribosomal protein genes in bighead carp and their expression in response to microcystin-LR. The Journal of Toxicological Sciences. 41:293-302
- Chatzopoulou, A., Roy, U., Meijer, A.H., Alia, A., Spaink, H.P., Schaaf, M.J. (2015) Transcriptional and Metabolic Effects of Glucocorticoid Receptor α and β Signaling in Zebrafish. Endocrinology. 156(5):1757-69
- Li, Z., Zheng, W., Wang, Z., Zeng, Z., Zhan, H., Li, C., Zhou, L., Yan, C., Spitsbergen, J.M., and Gong, Z. (2013) A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors. Disease models & mechanisms. 427(1):223-226
- Provost, E., Weier, C.A., and Leach, S.D. (2013) Multiple ribosomal proteins are expressed at high levels in developing zebrafish endoderm and are required for normal exocrine pancreas development. Zebrafish. 10(2):161-169
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Lai, K., Amsterdam, A., Farrington, S., Bronson, R.T., Hopkins, N., and Lees, J.A. (2009) Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(1):76-85
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