Gene
sap30l
- ID
- ZDB-GENE-030131-5287
- Name
- sap30-like
- Symbol
- sap30l Nomenclature History
- Previous Names
-
- wu:fa26a11
- wu:fc10g12
- wu:fe36f07
- zgc:77367 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including non-sequence-specific DNA binding activity, bending; phosphatidylinositol phosphate binding activity; and zinc ion binding activity. Acts upstream of or within heart looping. Predicted to be located in nucleolus. Predicted to be part of histone deacetylase complex. Is expressed in several structures, including anterior neural rod; pectoral fin bud; pericardial region; pleuroperitoneal region; and trunk. Orthologous to several human genes including SAP30L (SAP30 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77367 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Teittinen et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-sap30l | N/A | Teittinen et al., 2012 |
| MO2-sap30l | N/A | Teittinen et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR025717 | Histone deacetylase complex subunit SAP30 zinc-finger |
| Domain | IPR025718 | Histone deacetylase complex subunit SAP30, Sin3 binding domain |
| Family | IPR024145 | Histone deacetylase complex subunit SAP30/SAP30-like |
| Homologous_superfamily | IPR038291 | SAP30, C-terminal domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Histone deacetylase complex subunit SAP30/SAP30-like | Histone deacetylase complex subunit SAP30, Sin3 binding domain | Histone deacetylase complex subunit SAP30 zinc-finger | SAP30, C-terminal domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q6NYV5 | InterPro | 178 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sap30l-201
(1)
|
Ensembl | 1,953 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-162O18 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-409B12 | ZFIN Curated Data | |
| Encodes | EST | fa26a11 | ||
| Encodes | EST | fc10g12 | ||
| Encodes | EST | fe36f07 | ||
| Encodes | cDNA | MGC:77367 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214703 (1) | 1549 nt | ||
| Genomic | GenBank:FO704804 (1) | 39115 nt | ||
| Polypeptide | UniProtKB:Q6NYV5 (1) | 178 aa |
- Raman, R., Fallatah, W., Al Qaryoute, A., Dhinoja, S., Jagadeeswaran, P. (2021) Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Scientific Reports. 11:15238
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Teittinen, K.J., Gronroos, T., Parikka, M., Junttila, S., Uusimaki, A., Laiho, A., Korkeamaki, H., Kurppa, K., Turpeinen, H., Pesu, M., Gyenesei, A., Ramet, M., and Lohi, O. (2012) SAP30L (Sin3A-associated protein 30-like) is involved in regulation of cardiac development and hematopoiesis in zebrafish embryos. Journal of cellular biochemistry. 113(12):3843-3852
- Zou, J., Li, W.Q., Li, Q., Li, X.Q., Zhang, J.T., Liu, G.Q., Chen, J., Qiu, X.X., Tian, F.J., Wang, Z.Z., Zhu, N., Qin, Y.W., Shen, B., Liu, T.X., and Jing, Q. (2011) Two Functional MicroRNA-126s Repress a Novel Target Gene p21-Activated Kinase 1 to Regulate Vascular Integrity in Zebrafish. Circulation research. 108(2):201-209
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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