Gene

slc25a4

ID
ZDB-GENE-030131-5275
Name
solute carrier family 25 member 4
Symbol
slc25a4 Nomenclature History
Previous Names
  • fa22e07
  • wu:fa22e07
  • zgc:77591
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have ATP transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to localize to integral component of membrane and mitochondrial inner membrane. Is expressed in cephalic musculature; hypaxial myotome region; musculature system; myotome; and somite. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to human SLC25A4 (solute carrier family 25 member 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With slc25a4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2 Alliance Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 2 609283
mitochondrial DNA depletion syndrome 12a Alliance Mitochondrial DNA depletion syndrome 12A (cardiomyopathic type) AD 617184
mitochondrial DNA depletion syndrome 12b Alliance Mitochondrial DNA depletion syndrome 12B (cardiomyopathic type) AR 615418
Associated With slc25a4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR002067 Mitochondrial carrier protein
Family IPR002113 ADP/ATP carrier protein, eukaryotic type
Homologous_superfamily IPR023395 Mitochondrial carrier domain superfamily
Repeat IPR018108 Mitochondrial substrate/solute carrier
Domain Details Per Protein
Protein Length ADP/ATP carrier protein, eukaryotic type Mitochondrial carrier domain superfamily Mitochondrial carrier protein Mitochondrial substrate/solute carrier
UniProtKB:Q6NX10 298
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA slc25a4-201 (1) Havana 1434 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations