Gene

eif2s1a

ID

ZDB-GENE-030131-526

Name

eukaryotic translation initiation factor 2, subunit 1 alpha a

Symbol

eif2s1a Nomenclature History

Previous Names

eif2s1l
fb36a08
wu:fb36a08 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable ribosome binding activity and translation initiation factor activity. Predicted to act upstream of or within translational initiation. Predicted to be located in cytoplasm. Predicted to be part of several cellular components, including eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 2 complex; and eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56510 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With eif2s1a Human Ortholog

No data available

Associated With eif2s1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003029	S1 domain
Domain	IPR044126	IF2a, S1-like domain
Family	IPR011488	Translation initiation factor 2, alpha subunit
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold
Homologous_superfamily	IPR024054	Translation initiation factor 2, alpha subunit, middle domain superfamily
Homologous_superfamily	IPR024055	Translation initiation factor 2, alpha subunit, C-terminal