Gene

ak2

ID
ZDB-GENE-030131-512
Name
adenylate kinase 2
Symbol
ak2 Nomenclature History
Previous Names
  • wu:fb34f05
  • wu:fj80e03
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have ATP binding activity and adenylate kinase activity. Involved in hematopoietic stem cell differentiation and leukocyte differentiation. Predicted to localize to mitochondrial intermembrane space. Used to study reticular dysgenesis. Human ortholog(s) of this gene implicated in reticular dysgenesis. Is expressed in head; hematopoietic system; and intermediate cell mass of mesoderm. Orthologous to human AK2 (adenylate kinase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ak2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
reticular dysgenesis Alliance Reticular dysgenesis 267500
Associated With ak2 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR033690 Adenylate kinase, conserved site
Domain IPR007862 Adenylate kinase, active site lid domain
Family IPR000850 Adenylate kinase/UMP-CMP kinase
Family IPR006259 Adenylate kinase subfamily
Family IPR028587 Adenylate kinase 2
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length Adenylate kinase 2 Adenylate kinase, active site lid domain Adenylate kinase, conserved site Adenylate kinase subfamily Adenylate kinase/UMP-CMP kinase P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A0F6PK88 235
UniProtKB:Q1L8L9 241
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations