Gene
gclc
- ID
- ZDB-GENE-030131-5056
- Name
- glutamate-cysteine ligase, catalytic subunit
- Symbol
- gclc Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have several functions, including anion binding activity; glutamate-cysteine ligase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including alpha-amino acid metabolic process; cell redox homeostasis; and glutathione biosynthetic process. Predicted to localize to glutamate-cysteine ligase complex. Human ortholog(s) of this gene implicated in cystic fibrosis; glutamate-cysteine ligase deficiency; hemolytic anemia; and myocardial infarction. Is expressed in several structures, including alar plate midbrain region; gut; intermediate cell mass of mesoderm; midbrain; and sensory system. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 29 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1049 (8 images)
- IMAGE:7153748 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la018448Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la018450Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa35401 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
congenital nonspherocytic hemolytic anemia 7 | Alliance | Anemia, congenital, nonspherocytic hemolytic, 7 | 230450 |
{Myocardial infarction, susceptibility to} | 608446 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Glutamate-cysteine ligase catalytic subunit | Glutamine synthetase/guanido kinase, catalytic domain |
---|---|---|---|
UniProtKB:Q6NV35
|
631 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-71K24 | ZFIN Curated Data | |
Encodes | EST | cb1049 | Thisse et al., 2001 | |
Encodes | EST | fe36e11 | ||
Encodes | EST | IMAGE:7153748 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:55305 | ZFIN Curated Data | |
Encodes | cDNA | MGC:85625 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191729 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_199277 (1) | 3186 nt | ||
Genomic | GenBank:CR376766 (2) | 155126 nt | ||
Polypeptide | UniProtKB:Q6NV35 (1) | 631 aa |
- Ajouaou, Y., Magnani, E., Madakashira, B., Jenkins, E., Sadler, K.C. (2023) atm Mutation and Oxidative Stress Enhance the Pre-Cancerous Effects of UHRF1 Overexpression in Zebrafish Livers. Cancers. 15(8):
- Badenetti, L., Manzoli, R., Rubin, M., Cozza, G., Moro, E. (2023) Monitoring Nrf2/ARE Pathway Activity with a New Zebrafish Reporter System. International Journal of Molecular Sciences. 24(7):
- Chang, S.H., Giong, H.K., Kim, D.Y., Kim, S., Oh, S., Yun, U.J., Lee, J.S., Park, K.W. (2023) Activation of Nrf2 by sulfuretin stimulates chondrocyte differentiation and increases bone lengths in zebrafish. BMB reports. 56:496501496-501
- Xu, F.H., Qiu, Y.Z., Zhang, Y., Yang, F.H., Ji, M.M., Liu, K.C., Jin, M., Zhang, S.S., Li, B. (2023) The molecular mechanism of three novel peptides from C-phycocyanin alleviates MPTP-induced Parkinson's disease-like pathology in zebrafish. Food & function. 14(13):6157-6171
- Xu, Y., Peng, T., Zhou, Q., Zhu, J., Liao, G., Zou, F., Meng, X. (2023) Evaluation of the oxidative toxicity induced by lead, manganese, and cadmium using genetically modified nrf2a-mutant zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 266:109550
- Chen, C., He, M., Li, X., Yu, L., Liu, Y., Yang, Y., Li, L., Jia, J., Li, B. (2022) H2O2/DEM-Promoted Maft Promoter Demethylation Drives Nrf2/ARE Activation in Zebrafish. Life (Basel, Switzerland). 12(9)
- Dixon, S.C., Calder, B.J., Lilya, S.M., Davies, B.M., Martin, A., Peterson, M., Hansen, J.M., Suli, A. (2022) Valproic acid affects neurogenesis during early optic tectum development in zebrafish. Biology Open. 12(1):
- Lasbleiz, C., Peyrel, A., Tarot, P., Sarniguet, J., Crouzier, L., Cubedo, N., Delprat, B., Rossel, M., Maurice, T., Liévens, J.C. (2022) Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling. Redox Biology. 58:102542102542
- Üstündağ, F.D., Ünal, İ., Üstündağ, Ü.V., Cansız, D., Beler, M., Karagöz, A., Kara Subaşat, H., Alturfan, A.A., Mega Tiber, P., Emekli-Alturfan, E. (2022) 3-Pyridinylboronic Acid Ameliorates Rotenone-Induced Oxidative Stress Through Nrf2 Target Genes in Zebrafish Embryos. Neurochemical research. 47(6):1553-1564
- Chen, J., Chen, Y., Zheng, Y., Zhao, J., Yu, H., Zhu, J., Li, D. (2021) Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro. Molecules. 26(18):
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