Gene

gclc

ID
ZDB-GENE-030131-5056
Name
glutamate-cysteine ligase, catalytic subunit
Symbol
gclc Nomenclature History
Previous Names
  • cb1049 (1)
  • fe36e11
  • wu:fe36e11 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have several functions, including anion binding activity; glutamate-cysteine ligase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including alpha-amino acid metabolic process; cell redox homeostasis; and glutathione biosynthetic process. Predicted to localize to glutamate-cysteine ligase complex. Human ortholog(s) of this gene implicated in cystic fibrosis; glutamate-cysteine ligase deficiency; hemolytic anemia; and myocardial infarction. Is expressed in several structures, including alar plate midbrain region; gut; intermediate cell mass of mesoderm; midbrain; and sensory system. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
27 figures from 15 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gclc Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
glutamate-cysteine ligase deficiency Alliance Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency 230450
{Myocardial infarction, susceptibility to} 608446
Associated With gclc Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR004308 Glutamate-cysteine ligase catalytic subunit
Homologous_superfamily IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
Domain Details Per Protein
Protein Length Glutamate-cysteine ligase catalytic subunit Glutamine synthetase/guanido kinase, catalytic domain
UniProtKB:Q7ZW37 631
UniProtKB:Q6NV35 631
UniProtKB:A8KBT3 222
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations