Gene

gclc

ID
ZDB-GENE-030131-5056
Name
glutamate-cysteine ligase, catalytic subunit
Symbol
gclc Nomenclature History
Previous Names
  • cb1049 (1)
  • fe36e11
  • wu:fe36e11 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have several functions, including anion binding activity; glutamate-cysteine ligase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including alpha-amino acid metabolic process; cell redox homeostasis; and glutathione biosynthetic process. Predicted to localize to glutamate-cysteine ligase complex. Human ortholog(s) of this gene implicated in cystic fibrosis; glutamate-cysteine ligase deficiency; hemolytic anemia; and myocardial infarction. Is expressed in several structures, including alar plate midbrain region; gut; intermediate cell mass of mesoderm; midbrain; and sensory system. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
29 figures from 17 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la018448TgTransgenic insertionUnknownUnknownDNA
la018450TgTransgenic insertionUnknownUnknownDNA
sa35401Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With gclc Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital nonspherocytic hemolytic anemia 7 Alliance Anemia, congenital, nonspherocytic hemolytic, 7 230450
{Myocardial infarction, susceptibility to} 608446
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Associated With gclc Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR004308 Glutamate-cysteine ligase catalytic subunit
Homologous_superfamily IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
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Domain Details Per Protein
Protein Length Glutamate-cysteine ligase catalytic subunit Glutamine synthetase/guanido kinase, catalytic domain
UniProtKB:Q6NV35 631
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 13
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA gclc-201 (1) Ensembl 3,045 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
1 - 7 of 7
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanGCLC6
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseGclc9
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
1 - 10 of 86
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