ZFIN is now using GRCz12tu for Genomic Data
Gene

sgsh

ID
ZDB-GENE-030131-4958
Name
N-sulfoglucosamine sulfohydrolase (sulfamidase)
Symbol
sgsh Nomenclature History
Previous Names
  • wu:fe14h11
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Predicted to enable N-sulfoglucosamine sulfohydrolase activity. Involved in heparan sulfate proteoglycan catabolic process. Acts upstream of or within locomotory behavior; microglial cell activation; and thigmotaxis. Predicted to be active in lysosome. Used to study mucopolysaccharidosis type IIIA. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIIA. Orthologous to human SGSH (N-sulfoglucosamine sulfohydrolase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Douek et al., 2021
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Douek et al., 2021
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sgsh Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
mucopolysaccharidosis type IIIA Alliance Mucopolysaccharidosis type IIIA (Sanfilippo A) 252900
Associated With sgsh Via Experimental Models
Human Disease Fish Conditions Citations
mucopolysaccharidosis type IIIA sgshmnu301/mnu301 (TU) standard conditions Douek et al., 2021
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR024607 Sulfatase, conserved site
Domain IPR000917 Sulfatase, N-terminal
Homologous_superfamily IPR017850 Alkaline-phosphatase-like, core domain superfamily
Domain Details Per Protein
Protein Additional Resources Length Alkaline-phosphatase-like, core domain superfamily Sulfatase, conserved site Sulfatase, N-terminal
UniProtKB:B0V3V9 InterPro 511
UniProtKB:A0AC58IER5 InterPro 423
UniProtKB:A0AC58IER7 InterPro 423
UniProtKB:A0AC58IER8 InterPro 423
UniProtKB:A0AC58IES2 InterPro 423
UniProtKB:A0AC58IET0 InterPro 423
UniProtKB:A0AC58IEU3 InterPro 423
UniProtKB:A0AC58IEU5 InterPro 423
UniProtKB:A0AC58IEU7 InterPro 423
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA sgsh-201 (1)
Ensembl
Ensembl 1,953 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Genome Browsers
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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