Gene

sgsh

ID

ZDB-GENE-030131-4958

Name

N-sulfoglucosamine sulfohydrolase (sulfamidase)

Symbol

sgsh Nomenclature History

Previous Names

wu:fe14h11

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Enables N-sulfoglucosamine sulfohydrolase activity. Involved in heparan sulfate proteoglycan catabolic process. Acts upstream of or within locomotory behavior; microglial cell activation; and thigmotaxis. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIIA. Orthologous to human SGSH (N-sulfoglucosamine sulfohydrolase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Douek et al., 2021

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Douek et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sgsh Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
mucopolysaccharidosis type IIIA	Alliance	Mucopolysaccharidosis type IIIA (Sanfilippo A)	252900

Associated With sgsh Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR024607	Sulfatase, conserved site
Domain	IPR000917	Sulfatase, N-terminal
Homologous_superfamily	IPR017850	Alkaline-phosphatase-like, core domain superfamily