Gene

fbxo28

ID

ZDB-GENE-030131-4665

Name

F-box protein 28

Symbol

fbxo28 Nomenclature History

Previous Names

fd49h06
si:ch211-178h7.5
wu:fd49h06

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to be involved in protein polyubiquitination. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 100. Orthologous to human FBXO28 (F-box protein 28).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa42105	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With fbxo28 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 100	Alliance	Developmental and epileptic encephalopathy 100	619777

Associated With fbxo28 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001810	F-box domain
Family	IPR039719	F-box only protein 28

Domain Details Per Protein

Protein	Additional Resources	Length	F-box domain	F-box only protein 28
UniProtKB:A0A8M1P937	InterPro	344

Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 13

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	fbxo28-201 (1) Ensembl	Ensembl		1,041 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-178H7	BX005147	ZFIN Curated Data
Contained in	BAC	DKEY-38O8	CU570800	ZFIN Curated Data
Encodes	EST	fd49h06	AW018765 AW019116

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001327835 (1)	2492 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX005147 (1)	147683 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A8M1P937 (1)	344 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	FBXO28	1	Ensembl:ENSG00000143756 Gene:23219 HGNC:29046 OMIM:609100	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Fbxo28	1	Ensembl:ENSMUSG00000047539 Gene:67948 MGI:1261890	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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