Gene
tcn2
- ID
- ZDB-GENE-030131-4648
- Name
- transcobalamin II
- Symbol
- tcn2 Nomenclature History
- Previous Names
-
- tcn2l
- si:ch211-102c2.6
- wu:fd46e10 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables cobalamin binding activity. Predicted to be involved in cobalamin transport. Predicted to act upstream of or within cobalt ion transport. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in intestine; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Parkinson's disease; megaloblastic anemia; and transcobalamin II deficiency. Orthologous to human TCN2 (transcobalamin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7162514 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Benoit et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| transcobalamin II deficiency | Alliance | Transcobalamin II deficiency | 275350 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| vitamin B12 deficiency | tcn2zf3057/zf3057 (AB/TU) | standard conditions | Benoit et al., 2021 |
| vitamin B12 deficiency | tcn2zf3057/zf3057 (AB/TU) | standard conditions | Benoit et al., 2021 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cobalamin (vitamin B12)-binding protein | Eukaryotic Cobalamin Transport | Transcobalamin-like, C-terminal domain |
|---|---|---|---|---|
|
UniProtKB:F2Z4S3
|
423 |
Interactions and Pathways
No data available
Plasmids
No data available