Gene
gtf2f1
- ID
- ZDB-GENE-030131-4557
- Name
- general transcription factor IIF, polypeptide 1
- Symbol
- gtf2f1 Nomenclature History
- Previous Names
-
- fd13c08
- wu:fd13c08
- zgc:56155
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II general transcription initiation factor activity and TFIIF-class transcription factor complex binding activity. Predicted to be involved in transcription initiation at RNA polymerase II promoter. Predicted to act upstream of or within positive regulation of transcription elongation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIIF complex. Is expressed in telencephalon. Orthologous to human GTF2F1 (general transcription factor IIF subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6908715 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR008851 | Transcription initiation factor IIF, alpha subunit |
| Homologous_superfamily | IPR011039 | Transcription Factor IIF, Rap30/Rap74, interaction |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Transcription Factor IIF, Rap30/Rap74, interaction | Transcription initiation factor IIF, alpha subunit | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q7ZV95 | InterPro | 443 | ||||
| UniProtKB:A0AB13AB08 | InterPro | 536 | ||||
| UniProtKB:A0AB32T7Y2 | InterPro | 561 | ||||
| UniProtKB:A0AB32T998 | InterPro | 558 | ||||
| UniProtKB:A0AB32TAS1 | InterPro | 560 | ||||
| UniProtKB:A0AB32TBT9 | InterPro | 539 | ||||
| UniProtKB:A0AB32TDH7 | InterPro | 559 | ||||
| UniProtKB:A0AB32TF26 | InterPro | 537 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gtf2f1-201
(1)
|
Ensembl | 2,281 nt | ||
| mRNA |
gtf2f1-202
(1)
|
Ensembl | 1,913 nt | ||
| mRNA |
gtf2f1-203
(1)
|
Ensembl | 1,901 nt | ||
| mRNA |
gtf2f1-205
(1)
|
Ensembl | 591 nt | ||
| mRNA |
gtf2f1-206
(1)
|
Ensembl | 1,036 nt | ||
| ncRNA |
gtf2f1-003
(1)
|
Ensembl | 785 nt | ||
| ncRNA |
gtf2f1-004
(1)
|
Ensembl | 624 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-80D13 | ||
| Encodes | EST | fd13c08 | ||
| Encodes | EST | IMAGE:6908715 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:56155 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192665 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423629 (1) | 2281 nt | ||
| Genomic | GenBank:BX510335 (1) | 76516 nt | ||
| Polypeptide | UniProtKB:A0AB32T7Y2 (1) | 561 aa |
- Boswell, M., Boswell, W., Lu, Y., Savage, M., Walter, R.B. (2020) Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Scientific Reports. 10:3321
- Shi, W., Shao, T., Li, J.Y., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2019) BTLA-HVEM Checkpoint Axis Regulates Hepatic Homeostasis and Inflammation in a ConA-Induced Hepatitis Model in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 203(9):2425-2442
- Lee, J., Freeman, J.L. (2016) Embryonic exposure to 10 μg L(-1) lead results in female-specific expression changes in genes associated with nervous system development and function and Alzheimer's disease in aged adult zebrafish brain. Metallomics : integrated biometal science. 8(6):589-96
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Jiang, L., Zhang, J., Wang, J.J., Wang, L., Zhang, L., Li, G., Yang, X., Ma, X., Sun, X., Cai, J., Zhang, J., Huang, X., Yu, M., Wang, X., Liu, F., Wu, C.I., He, C., Zhang, B., Ci, W., and Liu, J. (2013) Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell. 153(4):773-784
- Eckfeldt, C.E., Mendenhall, E.M., Flynn, C.M., Wang, T.F., Pickart, M.A., Grindle, S.M., Ekker, S.C., and Verfaillie, C.M. (2005) Functional analysis of human hematopoietic stem cell gene expression using zebrafish. PLoS Biology. 3(8):e254
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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