Gene
chd4b
- ID
- ZDB-GENE-030131-4532
- Name
- chromodomain helicase DNA binding protein 4b
- Symbol
- chd4b Nomenclature History
- Previous Names
-
- si:ch211-57k11.10
- wu:fb44b12
- wu:fd12d03 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including ATP hydrolysis activity; ATP-dependent chromatin remodeler activity; and histone binding activity. Predicted to be involved in chromatin remodeling. Predicted to be located in chromatin. Predicted to be part of NuRD complex. Predicted to be active in nucleus. Is expressed in blastomere; central nervous system; hematopoietic multipotent progenitor cell; and telencephalon. Human ortholog(s) of this gene implicated in Sifrim-Hitz-Weiss syndrome; colorectal cancer (multiple); lung cancer (multiple); and lymphoma. Orthologous to human CHD4 (chromodomain helicase DNA binding protein 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Sifrim-Hitz-Weiss syndrome | Alliance | Sifrim-Hitz-Weiss syndrome | 617159 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR002464 | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site |
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR000330 | SNF2, N-terminal |
| Domain | IPR000953 | Chromo/chromo shadow domain |
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR009462 | CHD subfamily II, SANT-like domain |
| Domain | IPR009463 | Domain of unknown function DUF1087 |
| Domain | IPR012957 | CHD, C-terminal 2 |
| Domain | IPR012958 | CHD, N-terminal |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR023780 | Chromo domain |
| Domain | IPR049730 | SNF2/RAD5-like, C-terminal helicase domain |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR016197 | Chromo-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR038718 | SNF2-like, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | CHD, C-terminal 2 | CHD, N-terminal | CHD subfamily II, SANT-like domain | Chromo/chromo shadow domain | Chromo domain | Chromo-like domain superfamily | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site | Domain of unknown function DUF1087 | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | SNF2-like, N-terminal domain superfamily | SNF2, N-terminal | SNF2/RAD5-like, C-terminal helicase domain | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PC64 | InterPro | 1948 | |||||||||||||||||||
| UniProtKB:A0A8M9PNR4 | InterPro | 1890 | |||||||||||||||||||
| UniProtKB:A0A8M9PDP3 | InterPro | 1949 | |||||||||||||||||||
| UniProtKB:A0A8N7T760 | InterPro | 1952 | |||||||||||||||||||
| UniProtKB:F1RBT2 | InterPro | 1953 | |||||||||||||||||||
| UniProtKB:A0A8M9PN35 | InterPro | 1891 | |||||||||||||||||||
| UniProtKB:A0AB32TNF9 | InterPro | 1890 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available