sh3gl1a

ID

ZDB-GENE-030131-4524

Name

SH3-domain GRB2-like 1a

Symbol

sh3gl1a Nomenclature History

Previous Names

eenb (1)
wu:fd12b05
wu:fy33c10
zgc:56637

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in endocytosis and membrane organization. Predicted to be located in early endosome membrane and podosome. Predicted to be active in several cellular components, including cytosol; glutamatergic synapse; and presynapse. Is expressed in several structures, including EVL; digestive system; epidermis; hatching gland; and periderm. Human ortholog(s) of this gene implicated in acute myeloid leukemia and high grade glioma. Orthologous to human SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56637 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sh3gl1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	Alliance	Leukemia, acute myeloid	601626

Associated With sh3gl1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001452	SH3 domain
Domain	IPR004148	BAR domain
Domain	IPR035824	Endophilin-A, SH3 domain
Family	IPR050384	Endophilin/SH3RF
Homologous_superfamily	IPR027267	AH/BAR domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily