Gene
rbbp4
- ID
- ZDB-GENE-030131-445
- Name
- retinoblastoma binding protein 4
- Symbol
- rbbp4 Nomenclature History
- Previous Names
-
- rbb4
- wu:fb33a09
- wu:fb40e10
- zgc:55349
- zgc:77854
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable histone binding activity. Predicted to contribute to ATP-dependent activity, acting on DNA. Acts upstream of or within fin regeneration. Predicted to be located in chromosome, telomeric region. Predicted to be part of CAF-1 complex; ESC/E(Z) complex; and NuRD complex. Predicted to be active in nucleus. Is expressed in gonad; muscle; nervous system; and pectoral fin. Orthologous to human RBBP4 (RB binding protein 4, chromatin remodeling factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| is60 | Allele with one deletion | Exon 2 | Frameshift | CRISPR | |
| is62Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| is94Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| sa15025 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23554 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-rbbp4 | (3) | |
| CRISPR2-rbbp4 | Liu et al., 2022 | |
| MO1-rbbp4 | N/A | Pfefferli et al., 2014 |
| MO2-rbbp4 | N/A | Huang et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR022052 | Histone-binding protein RBBP4-like, N-terminal |
| Family | IPR050459 | WD repeat RBAP46/RBAP48/MSI1 |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | G-protein beta WD-40 repeat | Histone-binding protein RBBP4-like, N-terminal | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | WD repeat RBAP46/RBAP48/MSI1 |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6P3H7 | InterPro | 424 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(ubb:rbbp4-2A-GFP) |
| 1 | Schultz-Rogers et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-25A3 | ZFIN Curated Data | |
| Contains | SNP | rs3728987 | ZFIN Curated Data | |
| Contains | SNP | rs3728988 | ZFIN Curated Data | |
| Encodes | EST | fb33a09 | ||
| Encodes | EST | fb40e10 | ||
| Encodes | EST | fc32h01 | Rauch et al., 2003 | |
| Encodes | EST | IMAGE:7146730 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:55349 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77854 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174472 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212595 (1) | 2038 nt | ||
| Genomic | GenBank:BX465206 (1) | 161014 nt | ||
| Polypeptide | UniProtKB:Q6P3H7 (1) | 424 aa |
- Liu, F., Kambakam, S., Almeida, M.P., Ming, Z., Welker, J.M., Wierson, W.A., Schultz-Rogers, L.E., Ekker, S.C., Clark, K.J., Essner, J.J., McGrail, M. (2022) Cre/lox regulated conditional rescue and inactivation with zebrafish UFlip alleles generated by CRISPR-Cas9 targeted integration. eLIFE. 11:
- Schultz-Rogers, L.E., Thayer, M.L., Kambakam, S., Wierson, W.A., Helmer, J.A., Wishman, M.D., Wall, K.A., Greig, J.L., Forsman, J.L., Puchhalapalli, K., Nair, S., Weiss, T.J., Luiken, J.M., Blackburn, P.R., Ekker, S.C., Kool, M., McGrail, M. (2022) Rbbp4 loss disrupts neural progenitor cell cycle regulation independent of Rb and leads to Tp53 acetylation and apoptosis. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(8):1267-1290
- Jin, X., Liu, W., Miao, J., Tai, Z., Li, L., Guan, P., Liu, J.X. (2021) Copper ions impair zebrafish skeletal myofibrillogenesis via epigenetic regulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35:e21686
- Matrone, G., Jung, S.Y., Choi, J.M., Jain, A., Leung, H.E., Rajapakshe, K., Coarfa, C., Rodor, J., Denvir, M.A., Baker, A.H., Cooke, J.P. (2021) Nuclear S-nitrosylation impacts tissue regeneration in zebrafish. Nature communications. 12:6282
- Chrispijn, N.D., Andralojc, K.M., Castenmiller, C., Kamminga, L.M. (2018) Gene expression profile of a selection of Polycomb Group genes during zebrafish embryonic and germ line development. PLoS One. 13:e0200316
- Schultz, L.E., Haltom, J.A., Almeida, M.P., Wierson, W.A., Solin, S.L., Weiss, T.J., Helmer, J.A., Sandquist, E.J., Shive, H.R., McGrail, M. (2018) Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and proliferation. Disease models & mechanisms. 11(6)
- Wang, S., Yang, Q., Wang, Z., Feng, S., Li, H., Ji, D., Zhang, S. (2018) Evolutionary and Expression Analyses Show Co-option of khdrbs Genes for Origin of Vertebrate Brain.. Frontiers in genetics. 8:225
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Choi, T.Y., Khaliq, M., Tsurusaki, S., Ninov, N., Stainier, D.Y.R., Tanaka, M., Shin, D. (2017) Bmp Signaling Governs Biliary-Driven Liver Regeneration in Zebrafish via Tbx2b and Id2a. Hepatology (Baltimore, Md.). 66(5):1616-1630
- Leontovich, A.A., Intine, R.V., Sarras, M.P. (2016) Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes. Journal of Diabetes Research. 2016:2860780
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