Gene
ppp4ca
- ID
- ZDB-GENE-030131-4433
- Name
- protein phosphatase 4, catalytic subunit a
- Symbol
- ppp4ca Nomenclature History
- Previous Names
-
- ppp4c (1)
- wu:fd05e08
- zgc:56413
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine phosphatase activity. Acts upstream of or within angiogenesis; central nervous system development; and determination of ventral identity. Predicted to be located in centrosome. Predicted to be active in cytoplasm and nucleus. Is expressed in blastoderm; brain; and head. Orthologous to human PPP4C (protein phosphatase 4 catalytic subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56413 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024060Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028886Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa33179 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ppp4ca | N/A | Kalén et al., 2009 |
| MO2-ppp4ca | N/A | Kalén et al., 2009 |
| MO3-ppp4ca | N/A | Jia et al., 2012 |
| MO4-ppp4ca | N/A | Jia et al., 2012 |
| MO5-ppp4ca | N/A | (2) |
| MO6-ppp4ca | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004843 | Calcineurin-like phosphoesterase domain, ApaH type |
| Domain | IPR006186 | Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase |
| Family | IPR047129 | Serine/Threonine protein phosphatase PP2A-like |
| Homologous_superfamily | IPR029052 | Metallo-dependent phosphatase-like |
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Domain Details Per Protein
| Protein | Length | Calcineurin-like phosphoesterase domain, ApaH type | Metallo-dependent phosphatase-like | Serine/Threonine protein phosphatase PP2A-like | Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase |
|---|---|---|---|---|---|
|
UniProtKB:B7ZVT0
|
311 | ||||
|
UniProtKB:A8WGP3
|
311 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ppp4ca-201
(1)
|
Ensembl | 1,822 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-33I10 | ZFIN Curated Data | |
| Encodes | EST | fd05e08 | ||
| Encodes | cDNA | MGC:56413 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174832 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198422 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198424 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001110414 (1) | 1533 nt | ||
| Genomic | GenBank:BX511232 (1) | 171843 nt | ||
| Polypeptide | UniProtKB:A8WGP3 (1) | 311 aa |
- Kasap, M., Rajani, V., Rajani, J., Dwyer, D.S. (2018) Surprising conservation of schizophrenia risk genes in lower organisms reflects their essential function and the evolution of genetic liability. Schizophrenia research. 202:120-128
- McCammon, J.M., Blaker-Lee, A., Chen, X., Sive, H. (2017) The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. Human molecular genetics. 26:3699-3712
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Sreenivasan, R., Jiang, J., Wang, X., Bartfai, R., Kwan, H.Y., Christoffels, A., and Orban, L. (2014) Gonad Differentiation in Zebrafish Is Regulated by the Canonical Wnt Signaling Pathway. Biology of reproduction. 90(2):45
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Ahn, D., You, K.H., and Kim, C.H. (2012) Evolution of the Tbx6/16 Subfamily Genes in Vertebrates: Insights from Zebrafish. Mol. Biol. Evol.. 29(12):3959-3983
- Blaker-Lee, A., Gupta, S., McCammon, J.M., De Rienzo, G., and Sive, H. (2012) Zebrafish homologs of 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes. Disease models & mechanisms. 5(6):834-851
- Jia, S., Dai, F., Wu, D., Lin, X., Xing, C., Xue, Y., Wang, Y., Xiao, M., Wu, W., Feng, X.H., and Meng, A. (2012) Protein Phosphatase 4 Cooperates with Smads to Promote BMP Signaling in Dorsoventral Patterning of Zebrafish Embryos. Developmental Cell. 22(5):1065-1078
- Kalén, M., Wallgard, E., Asker, N., Nasevicius, A., Athley, E., Billgren, E., Larson, J.D., Wadman, S.A., Norseng, E., Clark, K.J., He, L., Karlsson-Lindahl, L., Häger, A.K., Weber, H., Augustin, H., Samuelsson, T., Kemmet, C.K., Utesch, C.M., Essner, J.J., Hackett, P.B., and Hellström, M. (2009) Combination of reverse and chemical genetic screens reveals angiogenesis inhibitors and targets. Chemistry & Biology. 16(4):432-441
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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