Gene
pof1b
- ID
- ZDB-GENE-030131-4287
- Name
- POF1B actin binding protein
- Symbol
- pof1b Nomenclature History
- Previous Names
-
- fc88b11
- si:dkeyp-8h9.2
- wu:fa99b01
- wu:fc88b11 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization; bicellular tight junction assembly; and epithelial cell morphogenesis. Predicted to be active in actin filament; adherens junction; and bicellular tight junction. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 2B. Orthologous to human POF1B (POF1B actin binding protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
primary ovarian insufficiency 2B | Alliance | ?Premature ovarian failure 2B | 300604 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | POF1B, helix-loop-helix domain | Protein POF1B |
---|---|---|---|---|
UniProtKB:A0A8M9PDM7 | InterPro | 592 | ||
UniProtKB:A0A2R8PYS8 | InterPro | 592 | ||
UniProtKB:A0AB32TCG3 | InterPro | 515 | ||
UniProtKB:A0AB32TP57 | InterPro | 515 | ||
UniProtKB:A0AB40E7W1 | InterPro | 516 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-241L3 | ZFIN Curated Data | |
Contained in | BAC | DKEYP-8H9 | ZFIN Curated Data | |
Encodes | EST | fa99b01 | ||
Encodes | EST | fc88b11 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_068218979 (1) | 2578 nt | ||
Genomic | GenBank:BX936451 (1) | 169828 nt | ||
Polypeptide | UniProtKB:A0A2R8PYS8 (1) | 592 aa |
- Huang, L., Urasaki, A., Inagaki, N. (2019) Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in the zebrafish brain. Scientific Reports. 9:1799
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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