Gene
sppl2
- ID
- ZDB-GENE-030131-4265
- Name
- signal peptide peptidase-like 2
- Symbol
- sppl2 Nomenclature History
- Previous Names
-
- wu:fc16e01
- wu:fc85d12
- zgc:136525
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable aspartic endopeptidase activity, intramembrane cleaving. Acts upstream of or within negative regulation of coagulation. Predicted to be located in endosome membrane. Predicted to be active in bounding membrane of organelle and endoplasmic reticulum membrane. Orthologous to human SPPL2B (signal peptide peptidase like 2B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Krawitz et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Pickart et al., 2006
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | PA domain | PA domain superfamily | Peptidase A22B, signal peptide peptidase | Presenilin/signal peptide peptidase |
|---|---|---|---|---|---|---|
| UniProtKB:F1QYI0 | InterPro | 555 | ||||
| UniProtKB:A0A8M9QFY1 | InterPro | 504 | ||||
| UniProtKB:A0A8M9QFX8 | InterPro | 529 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available