Gene

pars2

ID
ZDB-GENE-030131-4219
Name
prolyl-tRNA synthetase 2, mitochondrial
Symbol
pars2 Nomenclature History
Previous Names
  • fc83e06
  • wu:fc83e06
  • zgc:77163 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 75. Orthologous to human PARS2 (prolyl-tRNA synthetase 2, mitochondrial).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pars2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 75 Alliance Developmental and epileptic encephalopathy 75 618437
Associated With pars2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
Domain IPR004154 Anticodon-binding
Domain IPR006195 Aminoacyl-tRNA synthetase, class II
Domain IPR033730 Prokaryote proline-tRNA ligase core domain
Family IPR002316 Proline-tRNA ligase, class IIa
Homologous_superfamily IPR036621 Anticodon-binding domain superfamily
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class II Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) Anticodon-binding Anticodon-binding domain superfamily Prokaryote proline-tRNA ligase core domain Proline-tRNA ligase, class IIa
UniProtKB:Q6P0C4 477
UniProtKB:F1QHZ4 477
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations