ZFIN is now using GRCz12tu for Genomic Data
Gene
mark2a
- ID
- ZDB-GENE-030131-4145
- Name
- MAP/microtubule affinity-regulating kinase 2a
- Symbol
- mark2a Nomenclature History
- Previous Names
-
- fc75f05
- si:dkey-175m17.8
- wu:fc75f05 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable tau-protein kinase activity. Predicted to be involved in intracellular signal transduction and microtubule cytoskeleton organization. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in dendrite and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human MARK2 (microtubule affinity regulating kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Intellectual developmental disorder, autosomal dominant 76 | 621285 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001772 | Kinase associated domain 1 (KA1) |
| Domain | IPR015940 | Ubiquitin-associated domain |
| Domain | IPR049508 | Serine/threonine-protein kinase MARK 1-4, catalytic domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR028375 | KA1 domain/Ssp2, C-terminal |
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
mark2a-207
(1)
|
Ensembl | 854 nt | ||
| mRNA |
mark2a-201
(1)
|
Ensembl | 2,280 nt | ||
| mRNA |
mark2a-203
(1)
|
Ensembl | 455 nt | ||
| mRNA |
mark2a-204
(1)
|
Ensembl | 726 nt | ||
| mRNA |
mark2a-205
(1)
|
Ensembl | 3,084 nt | ||
| mRNA |
mark2a-206
(1)
|
Ensembl | 419 nt | ||
| mRNA |
mark2a-208
(1)
|
Ensembl | 2,271 nt | ||
| ncRNA |
mark2a-006
(1)
|
Ensembl | 841 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers