Gene
kmt2e
- ID
- ZDB-GENE-030131-4120
- Name
- lysine (K)-specific methyltransferase 2E
- Symbol
- kmt2e Nomenclature History
- Previous Names
-
- mll5
- wu:fc74b02
- zgc:64223
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have metal ion binding activity. Human ortholog(s) of this gene implicated in autistic disorder and cervical cancer. Is expressed in central nervous system and intermediate cell mass of mesoderm. Orthologous to human KMT2E (lysine methyltransferase 2E).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64223 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| O'Donnell-Luria-Rodan syndrome | 618512 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR001214 | SET domain |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR044434 | KMT2E, SET domain |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Length | KMT2E, SET domain | SET domain | SET domain superfamily | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BC51
|
1598 | ||||||||
|
UniProtKB:A0A8N7UVB9
|
1631 | ||||||||
|
UniProtKB:A0A8M9Q6C7
|
1655 | ||||||||
|
UniProtKB:A0A8M2BC59
|
1622 |
Interactions and Pathways
No data available
Plasmids
No data available