Gene
khdc4
- ID
- ZDB-GENE-030131-405
- Name
- KH domain containing 4, pre-mRNA splicing factor
- Symbol
- khdc4 Nomenclature History
- Previous Names
-
- kiaa0907
- si:zfos-1192g2.2
- wu:fb26g02
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity. Predicted to be involved in mRNA splice site recognition. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in cytoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in nucleus. Orthologous to human KHDC4 (KH domain containing 4, pre-mRNA splicing factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55537 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR047889 | KHDC4, second type I KH domain |
| Domain | IPR047890 | KHDC4, first type I KH domain |
| Domain | IPR055256 | KHDC4/BBP-like, KH-domain type I |
| Family | IPR031121 | KH domain containing protein RIK/BLOM7 |
| Homologous_superfamily | IPR036612 | K Homology domain, type 1 superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | KHDC4/BBP-like, KH-domain type I | KHDC4, first type I KH domain | KHDC4, second type I KH domain | KH domain containing protein RIK/BLOM7 | K Homology domain, type 1 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1QQM1 | InterPro | 570 | |||||
| UniProtKB:A0A8M3AR35 | InterPro | 570 | |||||
| UniProtKB:A0A8M2BH01 | InterPro | 571 | |||||
| UniProtKB:A0A8M3ATY7 | InterPro | 571 | |||||
| UniProtKB:A0A8M3AJJ6 | InterPro | 572 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
khdc4-201
(1)
|
Ensembl | 2,044 nt | ||
| mRNA |
khdc4-204
(1)
|
Ensembl | 2,040 nt | ||
| ncRNA |
kiaa0907-002
(1)
|
Ensembl | 722 nt | ||
| ncRNA |
kiaa0907-003
(1)
|
Ensembl | 861 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-1192G2 | ZFIN Curated Data | |
| Encodes | EST | fb26g02 | ||
| Encodes | cDNA | MGC:55537 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77386 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212593 (1) | 2096 nt | ||
| Genomic | GenBank:CU861504 (1) | 40847 nt | ||
| Polypeptide | UniProtKB:A0A8M3AJJ6 (1) | 572 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Sharma, M.K., Denovan-Wright, E.M., Boudreau, M.E., and Wright, J.M. (2003) A cellular retinoic acid-binding protein from zebrafish (Danio rerio): cDNA sequence, phylogenetic analysis, mRNA expression, and gene linkage mapping. Gene. 311:119-128
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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