Gene

calr

ID
ZDB-GENE-030131-4042
Name
calreticulin
Symbol
calr Nomenclature History
Previous Names
  • calrl2
  • fc66d10
  • wu:fc66d10
  • wu:fj50c03
  • zgc:66153
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity. Predicted to be involved in endoplasmic reticulum unfolded protein response and protein folding. Predicted to localize to endoplasmic reticulum membrane. Is expressed in several structures, including hatching gland; nervous system; notochord; polster; and trigeminal placode. Human ortholog(s) of this gene implicated in essential thrombocythemia; myelofibrosis; sideroblastic anemia; and thrombocytosis. Orthologous to human CALR (calreticulin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With calr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
essential thrombocythemia Alliance Thrombocythemia, somatic 187950
myelofibrosis Alliance Myelofibrosis, somatic 254450
Associated With calr Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018124 Calreticulin/calnexin, conserved site
Family IPR001580 Calreticulin/calnexin
Family IPR009169 Calreticulin
Homologous_superfamily IPR009033 Calreticulin/calnexin, P domain superfamily
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Domain Details Per Protein
Protein Length Calreticulin Calreticulin/calnexin Calreticulin/calnexin, conserved site Calreticulin/calnexin, P domain superfamily Concanavalin A-like lectin/glucanase domain superfamily
UniProtKB:F1Q8W8 417
UniProtKB:Q6PFP8 419
UniProtKB:A0A0B5JK63 417
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations