Gene
calr
- ID
- ZDB-GENE-030131-4042
- Name
- calreticulin
- Symbol
- calr Nomenclature History
- Previous Names
-
- calrl2
- fc66d10
- wu:fc66d10
- wu:fj50c03
- zgc:66153
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Predicted to be involved in protein folding and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including hatching gland; nervous system; notochord; polster; and trigeminal placode. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung cancer (multiple); and thrombocytosis. Orthologous to human CALR (calreticulin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66153 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| essential thrombocythemia | Alliance | Thrombocythemia, somatic | 187950 |
| myelofibrosis | Alliance | Myelofibrosis, somatic | 254450 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018124 | Calreticulin/calnexin, conserved site |
| Family | IPR001580 | Calreticulin/calnexin |
| Family | IPR009169 | Calreticulin |
| Homologous_superfamily | IPR009033 | Calreticulin/calnexin, P domain superfamily |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
Domain Details Per Protein
| Protein | Length | Calreticulin | Calreticulin/calnexin | Calreticulin/calnexin, conserved site | Calreticulin/calnexin, P domain superfamily | Concanavalin A-like lectin/glucanase domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:F1Q8W8
|
417 |
Interactions and Pathways
No data available
Plasmids
No data available