Gene

greb1l

ID
ZDB-GENE-030131-4022
Name
GREB1 like retinoic acid receptor coactivator
Symbol
greb1l Nomenclature History
Previous Names
  • fc65f09
  • si:dkey-203o21.1
  • si:dkey-264l15.1
  • wu:fc55e03
  • wu:fc65f09 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Involved in pronephros development. Predicted to localize to integral component of membrane. Is expressed in central nervous system and mesoderm. Used to study renal agenesis. Human ortholog(s) of this gene implicated in renal agenesis. Orthologous to human GREB1L (GREB1 like retinoic acid receptor coactivator).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With greb1l Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 80 Alliance Deafness, autosomal dominant 80 619274
Renal hypodysplasia/aplasia 3 617805
Associated With greb1l Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR046926 GREB1, N-terminal domain
Domain IPR046927 GREB1-like, C-terminal domain
Domain IPR048657 GREB1-like, circularly permuted SF2 helicase domain
Domain IPR048659 GREB1-like, second domain
Domain IPR049100 TET-Associated Glycosyltransferase
Family IPR028422 GREB1
Domain Details Per Protein
Protein Length GREB1 GREB1-like, circularly permuted SF2 helicase domain GREB1-like, C-terminal domain GREB1-like, second domain GREB1, N-terminal domain TET-Associated Glycosyltransferase
UniProtKB:B8JKP6 1942
UniProtKB:A0A8M9NZP6 1942
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Note
Woods, et al. (2005. Genome Res. 15:1307-1314.) report this gene to be the ortholog of human GREB1 based on amino acid similarity. Subsequent analysis suggests it is the ortholog of human GREB1L and mouse Greb1l based on amino acid similarity and conserved synteny.
Citations