Gene
greb1l
- ID
- ZDB-GENE-030131-4022
- Name
- GREB1 like retinoic acid receptor coactivator
- Symbol
- greb1l Nomenclature History
- Previous Names
-
- fc65f09
- si:dkey-203o21.1
- si:dkey-264l15.1
- wu:fc55e03
- wu:fc65f09 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Involved in pronephros development. Predicted to localize to integral component of membrane. Is expressed in central nervous system and mesoderm. Used to study renal agenesis. Human ortholog(s) of this gene implicated in renal agenesis. Orthologous to human GREB1L (GREB1 like retinoic acid receptor coactivator).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal dominant nonsyndromic deafness 80 | Alliance | Deafness, autosomal dominant 80 | 619274 |
Renal hypodysplasia/aplasia 3 | 617805 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
renal agenesis | greb1lrdu1000/rdu1000 | standard conditions | Sanna-Cherchi et al., 2017 |
renal agenesis | EKW + MO2-greb1l | standard conditions | Sanna-Cherchi et al., 2017 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | GREB1 | GREB1-like, circularly permuted SF2 helicase domain | GREB1-like, C-terminal domain | GREB1-like, second domain | GREB1, N-terminal domain | TET-Associated Glycosyltransferase |
---|---|---|---|---|---|---|---|
UniProtKB:B8JKP6
|
1942 | ||||||
UniProtKB:A0A8M9NZP6
|
1942 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
greb1l-201
(1)
|
Ensembl | 8900 nt | |
mRNA |
greb1l-203
(1)
|
Havana | 9009 nt | |
ncRNA |
greb1l-002
(1)
|
Havana | 851 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Woods, et al. (2005. Genome Res. 15:1307-1314.) report this gene to be the ortholog of human GREB1 based on amino acid similarity. Subsequent analysis suggests it is the ortholog of human GREB1L and mouse Greb1l based on amino acid similarity and conserved synteny.