Gene

src

ID
ZDB-GENE-030131-3809
Name
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Symbol
src Nomenclature History
Previous Names
  • fc54g04
  • sb:cb864
  • wu:fc54g04
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Involved in posterior lateral line neuromast primordium migration; regulation of vascular permeability; and response to yeast. Predicted to localize to several cellular components, including extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in colon cancer; colorectal cancer; ductal carcinoma in situ; prostate cancer; and type 2 diabetes mellitus. Is expressed in several structures, including adaxial cell; central nervous system; musculature system; periderm; and retina. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With src Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
colorectal cancer Alliance Colon cancer, advanced, somatic 114500
?Thrombocytopenia 6 616937
Associated With src Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000980 SH2 domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR001452 SH3 domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain SH2 domain SH2 domain superfamily SH3 domain SH3-like domain superfamily Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain
UniProtKB:A0A2R8QE56 540
UniProtKB:Q1JPZ3 534
UniProtKB:B2GS52 534
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations