Gene

tnika

ID
ZDB-GENE-030131-3767
Name
TRAF2 and NCK interacting kinase a
Symbol
tnika Nomenclature History
Previous Names
  • tnikl
  • fc52d11
  • misshapen 1 (1)
  • msn1 (1)
  • wu:fc52d11
  • zgc:63535
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Involved in convergent extension involved in gastrulation and regulation of cell shape. Predicted to localize to cytoplasm. Is expressed in nervous system and neural tube. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human TNIK (TRAF2 and NCK interacting kinase).
Genome Resources
Note
None
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Koppen et al., 2006
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tnika Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Mental retardation, autosomal recessive 54 617028
Associated With tnika Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR001180 Citron homology (CNH) domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Citron homology (CNH) domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q7SY42 1303
UniProtKB:A0A0R4IEP9 1332
UniProtKB:B0UY93 1303
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations