Gene

tnika

ID

ZDB-GENE-030131-3767

Name

TRAF2 and NCK interacting kinase a

Symbol

tnika Nomenclature History

Previous Names

tnikl
fc52d11
misshapen 1 (1)
msn1 (1)
wu:fc52d11
zgc:63535

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Involved in convergent extension involved in gastrulation and regulation of cell shape. Predicted to localize to cytoplasm. Is expressed in nervous system and neural tube. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human TNIK (TRAF2 and NCK interacting kinase).

Genome Resources

Note

None

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

MGC:63535 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Koppen et al., 2006
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tnika Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Mental retardation, autosomal recessive 54	617028

Associated With tnika Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001180	Citron homology (CNH) domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily