Gene

ptprn2

ID
ZDB-GENE-030131-3758
Name
protein tyrosine phosphatase receptor type N2
Symbol
ptprn2 Nomenclature History
Previous Names
  • fc52a08
  • IA-2[b] (1)
  • im:7153814
  • wu:fc52a08 (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in insulin secretion involved in cellular response to glucose stimulus and regulation of secretion. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in transport vesicle membrane. Predicted to be active in secretory granule and synapse. Is expressed in brain. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Orthologous to human PTPRN2 (protein tyrosine phosphatase receptor type N2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
1 - 9 of 9
Show
Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-ptprn2
    (3)
    CRISPR2-ptprn2
      Varshney et al., 2015
      CRISPR3-ptprn2
        (3)
        1 - 3 of 3
        Show
        Human Disease
        Associated With ptprn2 Human Ortholog
        No data available
        Associated With ptprn2 Via Experimental Models
        No data available
        Gene Ontology
        Protein Domains
        Domain, Family, and Site Summary
        Type InterPro ID Name
        Active_site IPR016130 Protein-tyrosine phosphatase, active site
        Domain IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
        Domain IPR000387 Tyrosine-specific protein phosphatases domain
        Domain IPR003595 Protein-tyrosine phosphatase, catalytic
        Domain IPR021613 Protein-tyrosine phosphatase receptor IA-2 ectodomain
        1 - 5 of 9 Show all
        Domain Details Per Protein
        Protein Additional Resources Length Protein-tyrosine phosphatase, active site Protein-tyrosine phosphatase, catalytic Protein-tyrosine phosphatase-like Protein-tyrosine phosphatase receptor IA-2 ectodomain Protein-tyrosine phosphatase receptor IA-2, ectodomain superfamily Receptor-type tyrosine-protein phosphatase-like N/N2 RESP18 domain Tyrosine-specific protein phosphatase, PTPase domain Tyrosine-specific protein phosphatases domain
        UniProtKB:F1QIB8 InterPro
        UniProtKB:A3KPJ4 InterPro 1027
        UniProtKB:A0A8M9QGN0 InterPro 989
        UniProtKB:A0A8M9Q7I8 InterPro 1011
        1 - 4 of 4
        Transcripts
        Genome Browsers
        Genome Build: GRCz11Chromosome: 7
        Type Name Annotation Method Has Havana Data Length (nt) Analysis
        mRNA ptprn2-201 (1) Ensembl 3,997 nt
        ncRNA ptprn2-002 (1) Ensembl 774 nt
        ncRNA ptprn2-003 (1) Ensembl 295 nt
        ncRNA ptprn2-004 (1) Ensembl 386 nt
        1 - 4 of 4
        Interactions and Pathways
        No data available
        Antibodies
        No data available
        Plasmids
        No data available
        Constructs
        No data available
        Marker Relationships
        Relationship Marker Type Marker Accession Numbers Citations
        Contained inBACCH211-212M22ZFIN Curated Data
        Contained inBACDKEY-65B16ZFIN Curated Data
        EncodesESTfc52a08
        EncodesESTIMAGE:7153814Thisse et al., 2004
        EncodescDNAMGC:195005ZFIN Curated Data
        1 - 5 of 5
        Show
        Sequences
        Orthology
        Comparative Orthology
        Alliance
        Gene Tree
        Ensembl
        Species Symbol Chromosome Accession # Evidence
        HumanPTPRN27
        Amino acid sequence comparison (2)
        Conserved genome location (synteny) (1)
        Nucleotide sequence comparison (1)
        MousePtprn212
        Nucleotide sequence comparison (1)
        Amino acid sequence comparison (1)
        Conserved genome location (synteny) (1)
        Citations
        1 - 10 of 10
        Show