Gene
adgrg1
- ID
- ZDB-GENE-030131-3671
- Name
- adhesion G protein-coupled receptor G1
- Symbol
- adgrg1 Nomenclature History
- Previous Names
-
- fc49b10
- gpr56
- wu:fc49b10
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity. Acts upstream of or within glial cell development and regulation of oligodendrocyte progenitor proliferation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including heart; liver; nervous system; pleuroperitoneal region; and trigeminal placode. Human ortholog(s) of this gene implicated in bilateral frontoparietal polymicrogyria and bilateral perisylvian polymicrogyria. Orthologous to human ADGRG1 (adhesion G protein-coupled receptor G1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7159602 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| bilateral frontoparietal polymicrogyria | Alliance | Cortical dysplasia, complex, with other brain malformations 14A, (bilateral frontoparietal) | 606854 |
| bilateral perisylvian polymicrogyria | Alliance | Cortical dysplasia, complex, with other brain malformations 14B, (bilateral perisylvian) | 615752 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000203 | GPS motif |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001315 | CARD domain |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Family | IPR000832 | GPCR, family 2, secretin-like |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR046338 | GAIN domain superfamily |
Domain Details Per Protein
| Protein | Length | CARD domain | Death-like domain superfamily | GAIN domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPS motif | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q59I63
|
648 | |||||||||
|
UniProtKB:F1QZM9
|
648 | |||||||||
|
UniProtKB:A0A1D5NSB4
|
513 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adgrg1-201
(1)
|
Ensembl | 2,823 nt | ||
| mRNA |
adgrg1-202
(1)
|
Ensembl | 4,138 nt |
Interactions and Pathways
No data available
Plasmids
No data available