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ZIRC
ZFIN ID: ZDB-GENE-030131-3654
Gene Name: sp8 transcription factor b
Gene Symbol: sp8b    Nomenclature History

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Previous Names: sp8l, fc48e06, wu:fc48e06, zgc:77258

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Exhibits double-stranded DNA binding activity. Involved in embryonic limb morphogenesis; embryonic pectoral fin morphogenesis; and positive regulation of fibroblast growth factor receptor signaling pathway. Predicted to localize to the nucleus. Is expressed in several structures, including apical ectodermal ridge pelvic fin bud; midbrain neural keel; nervous system; neural plate; and neural tube. Orthologous to human SP8 (Sp8 transcription factor).
Genome Resources: Alliance (1),  Gene:324931 (1),  Ensembl(GRCz11):ENSDARG00000056666 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22810 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-sp8b N/A 1
    MO2-sp8b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH sp8b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH sp8b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic limb morphogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function double-stranded DNA binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR013087 (1)
  • InterPro:IPR036236 (1)
  • PROSITE:PS00028 (1)
  • PROSITE:PS50157 (1)
  • Pfam:PF00096 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sp8b-201 (1)    Ensembl 1765
    sp8b-202 (1)    Ensembl 2045
    sp8b-203 (1)    Ensembl 875
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sp8b No data available
    MARKER RELATIONSHIPS
    sp8b Contained in: [BAC] CH73-226D12 (1) (order this), CH211-180P9 (1) (order this)
    sp8b Encodes: [EST] fc48e06, wz1241 (1)
    [cDNA] MGC:77258 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_205550 (1) 2053 bp
    Genomic GenBank:BX005032 (1) 155001 bp
    Select Tool
    Polypeptide UniProtKB:Q3L0W2 (1) 455 aa
    Sequence Clusters UniGene:29744 (1)
    Sequence Information (all 29)
    ORTHOLOGY for sp8b ( Chr: 16 )
    CITATIONS (31)