Gene

ptprna

ID
ZDB-GENE-030131-3511
Name
protein tyrosine phosphatase receptor type Na
Symbol
ptprna Nomenclature History
Previous Names
  • ptprn
  • fc43c04
  • IA-2 (1)
  • wu:fc43c04 (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in insulin secretion involved in cellular response to glucose stimulus and regulation of secretion. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in transport vesicle membrane. Predicted to be active in secretory granule and synapse. Is expressed in brain. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PTPRN (protein tyrosine phosphatase receptor type N).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la027120TgTransgenic insertionUnknownUnknownDNA
sa13683Allele with one point mutationUnknownSplice SiteENU
sa34556Allele with one point mutationUnknownPremature StopENU
1 - 3 of 3
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-ptprna
    Varshney et al., 2015
    CRISPR2-ptprna
      (3)
      CRISPR3-ptprna
        (3)
        1 - 3 of 3
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        Human Disease
        Associated With ptprna Human Ortholog
        No data available
        Associated With ptprna Via Experimental Models
        No data available
        Gene Ontology
        Protein Domains
        Domain, Family, and Site Summary
        Type InterPro ID Name
        Active_site IPR016130 Protein-tyrosine phosphatase, active site
        Domain IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
        Domain IPR000387 Tyrosine-specific protein phosphatases domain
        Domain IPR003595 Protein-tyrosine phosphatase, catalytic
        Domain IPR021613 Protein-tyrosine phosphatase receptor IA-2 ectodomain
        1 - 5 of 9 Show all
        Domain Details Per Protein
        Protein Additional Resources Length Protein-tyrosine phosphatase, active site Protein-tyrosine phosphatase, catalytic Protein-tyrosine phosphatase-like Protein-tyrosine phosphatase receptor IA-2 ectodomain Protein-tyrosine phosphatase receptor IA-2, ectodomain superfamily Receptor-type tyrosine-protein phosphatase-like N/N2 RESP18 domain Tyrosine-specific protein phosphatase, PTPase domain Tyrosine-specific protein phosphatases domain
        UniProtKB:A0A8M6Z8D6 InterPro 902
        UniProtKB:F1R8X1 InterPro 903
        1 - 2 of 2
        Transcripts
        Genome Browsers
        Genome Build: GRCz11Chromosome: 9
        Type Name Annotation Method Has Havana Data Length (nt) Analysis
        mRNA ptprna-201 (1) Ensembl 3,619 nt
        ncRNA ptprna-002 (1) Ensembl 1,444 nt
        1 - 2 of 2
        Interactions and Pathways
        No data available
        Antibodies
        No data available
        Plasmids
        No data available
        Constructs
        No data available
        Marker Relationships
        Relationship Marker Type Marker Accession Numbers Citations
        Contained inBACCH73-129N15ZFIN Curated Data
        Contained inBACCH73-199E17ZFIN Curated Data
        ContainsSNPrs3728452
          ZFIN Curated Data
          EncodesESTfc43c04
          EncodescDNAMGC:194996ZFIN Curated Data
          1 - 5 of 5
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          Sequences
          Orthology
          Comparative Orthology
          Alliance
          Gene Tree
          Ensembl
          Species Symbol Chromosome Accession # Evidence
          HumanPTPRN2
          Conserved genome location (synteny) (1)
          Amino acid sequence comparison (1)
          Nucleotide sequence comparison (1)
          MousePtprn1
          Conserved genome location (synteny) (1)
          Amino acid sequence comparison (1)
          Nucleotide sequence comparison (1)
          Citations