Gene
mylk3
- ID
- ZDB-GENE-030131-3497
- Name
- myosin light chain kinase 3
- Symbol
- mylk3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable myosin light chain kinase activity. Involved in sarcomerogenesis and ventricular cardiac myofibril assembly. Acts upstream of or within heart morphogenesis. Predicted to be active in cytoplasm. Predicted to colocalize with actin cytoskeleton. Is expressed in lens; notochord; pericardial region; and somite. Orthologous to human MYLK3 (myosin light chain kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Seguchi et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-mylk3 | N/A | Seguchi et al., 2007 |
| MO2-mylk3 | N/A | Seguchi et al., 2007 |
| MO3-mylk3 | N/A | Seguchi et al., 2007 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|
|
UniProtKB:A8C984
|
715 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001105587 (1) | 3210 nt | ||
| Genomic | GenBank:AL928906 (1) | 161527 nt | ||
| Polypeptide | UniProtKB:A8C984 (1) | 715 aa |
- Hesaraki, M., Bora, U., Pahlavan, S., Salehi, N., Mousavi, S.A., Barekat, M., Rasouli, S.J., Baharvand, H., Ozhan, G., Totonchi, M. (2022) A Novel Missense Variant in Actin Binding Domain of MYH7 Is Associated With Left Ventricular Noncompaction. Frontiers in cardiovascular medicine. 9:839862
- Fang, Y., Lai, K.S., She, P., Sun, J., Tao, W., Zhong, T.P. (2020) Tbx20 Induction Promotes Zebrafish Heart Regeneration by Inducing Cardiomyocyte Dedifferentiation and Endocardial Expansion. Frontiers in cell and developmental biology. 8:738
- Kossack, M., Hein, S., Juergensen, L., Siragusa, M., Benz, A., Katus, H.A., Most, P., Hassel, D. (2017) Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation. Journal of Molecular and Cellular Cardiology. 108:95-105
- Münch, J., Grivas, D., González-Rajal, Á., Torregrosa-Carrión, R., de la Pompa, J.L. (2017) Notch signalling restricts inflammation and serpine1 expression in the dynamic endocardium of the regenerating zebrafish heart.. Development (Cambridge, England). 144(8):1425-1440
- Xie, H., Fan, X., Tang, X., Wan, Y., Chen, F., Wang, X., Wang, Y., Li, Y., Tang, M., Liu, D., Jiang, Z., Liu, X., Yuan, W., Li, G., Ye, X., Zhou, J., Deng, Y., and Wu, X. (2013) The LIM protein fhlA is essential for heart chamber development in zebrafish embryos. Current Molecular Medicine. 13(6):979-92
- Tournoij, E., Weber, G.J., Akkerman, J.W., de Groot, P.G., Zon, L.I., Moll, F.L., and Schulte-Merker, S. (2010) Mlck1a is expressed in zebrafish thrombocytes and an essential component for thrombus formation. Journal of thrombosis and haemostasis : JTH. 8(3):588-595
- Webb, K.J., Norton, W.H.J., Trumbach, D., Meijer, A.H., Ninkovic, J., Topp, S., Heck, D., Marr, C., Wurst, W., Theis, F.J., Spaink, H.P., and Bally-Cuif, L. (2009) Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine. Genome biology. 10(7):R81
- Seguchi, O., Takashima, S., Yamazaki, S., Asakura, M., Asano, Y., Shintani, Y., Wakeno, M., Minamino, T., Kondo, H., Furukawa, H., Nakamaru, K., Naito, A., Takahashi, T., Ohtsuka, T., Kawakami, K., Isomura, T., Kitamura, S., Tomoike, H., Mochizuki, N., and Kitakaze, M. (2007) A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart. J. Clin. Invest.. 117(10):2812-2824
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