Gene

gldc

ID
ZDB-GENE-030131-340
Name
glycine dehydrogenase (decarboxylating)
Symbol
gldc Nomenclature History
Previous Names
  • fb23b05
  • wu:fb23b05
  • zgc:66198
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have glycine dehydrogenase (decarboxylating) activity. Predicted to be involved in glycine catabolic process and oxidation-reduction process. Predicted to localize to integral component of membrane. Used to study glycine encephalopathy. Human ortholog(s) of this gene implicated in glycine encephalopathy. Is expressed in central nervous system and digestive system. Orthologous to human GLDC (glycine decarboxylase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gldc Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
glycine encephalopathy 1 Alliance Glycine encephalopathy1 605899
Associated With gldc Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR049315 Glycine cleavage system P-protein, N-terminal domain
Domain IPR049316 Glycine dehydrogenase, C-terminal domain
Family IPR020581 Glycine cleavage system P protein
Homologous_superfamily IPR015421 Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily IPR015422 Pyridoxal phosphate-dependent transferase, small domain
Homologous_superfamily IPR015424 Pyridoxal phosphate-dependent transferase
Domain Details Per Protein
Protein Length Glycine cleavage system P protein Glycine cleavage system P-protein, N-terminal domain Glycine dehydrogenase, C-terminal domain Pyridoxal phosphate-dependent transferase Pyridoxal phosphate-dependent transferase, major domain Pyridoxal phosphate-dependent transferase, small domain
UniProtKB:A0A0G2KSN1 981
UniProtKB:E7FAR0 986
UniProtKB:Q6PFN9 983
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA gldc-201 (1) Ensembl 2,946 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations