Gene
gldc
- ID
- ZDB-GENE-030131-340
- Name
- glycine dehydrogenase (decarboxylating)
- Symbol
- gldc Nomenclature History
- Previous Names
-
- fb23b05
- wu:fb23b05
- zgc:66198
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have glycine dehydrogenase (decarboxylating) activity. Predicted to be involved in glycine catabolic process and oxidation-reduction process. Predicted to localize to integral component of membrane. Used to study glycine encephalopathy. Human ortholog(s) of this gene implicated in glycine encephalopathy. Is expressed in central nervous system and digestive system. Orthologous to human GLDC (glycine decarboxylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66198 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| glycine encephalopathy 1 | Alliance | Glycine encephalopathy1 | 605899 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| glycine encephalopathy | gldcudm301/udm301 | standard conditions | Riché et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR049315 | Glycine cleavage system P-protein, N-terminal domain |
| Domain | IPR049316 | Glycine dehydrogenase, C-terminal domain |
| Family | IPR020581 | Glycine cleavage system P protein |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
| Protein | Length | Glycine cleavage system P protein | Glycine cleavage system P-protein, N-terminal domain | Glycine dehydrogenase, C-terminal domain | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0G2KSN1
|
981 | ||||||
|
UniProtKB:E7FAR0
|
986 | ||||||
|
UniProtKB:Q6PFN9
|
983 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available