Gene

wdr81

ID

ZDB-GENE-030131-3389

Name

WD repeat domain 81

Symbol

wdr81 Nomenclature History

Previous Names

fc37g06
wu:fc37g06

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to enable phosphatidylinositol 3-kinase inhibitor activity. Predicted to be involved in aggrephagy; early endosome to late endosome transport; and ubiquitin-dependent protein catabolic process. Predicted to be located in bounding membrane of organelle and cytosol. Predicted to be active in mitochondrion. Is expressed in several structures, including heart; liver; nervous system; optic vesicle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 2 and hydrocephalus. Orthologous to human WDR81 (WD repeat domain 81).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wdr81 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 2	Alliance	Cerebellar ataxia, impaired intellectual development, and dysquilibrium syndrome 2	610185
		Hydrocephalus, congenital, 3, with brain anomalies	617967

Associated With wdr81 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000409	BEACH domain
Family	IPR052651	WD repeat-containing protein 81
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Homologous_superfamily	IPR036372	BEACH domain superfamily
Repeat	IPR001680	WD40 repeat