Gene
atad5b
- ID
- ZDB-GENE-030131-338
- Name
- ATPase family AAA domain containing 5b
- Symbol
- atad5b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and DNA clamp unloader activity. Acts upstream of or within positive regulation of RIG-I signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including eye; female organism; heart; liver; and pleuroperitoneal region. Orthologous to human ATAD5 (ATPase family AAA domain containing 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| kh34 | Allele with one deletion | Exon 6 | Frameshift | CRISPR | |
| kh35 | Allele with one deletion | Exon 6 | Frameshift | CRISPR | |
| sa1125 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15284 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16554 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17344 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40667 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-atad5b | Thomas et al., 2014 | |
| CRISPR2-atad5b | Thomas et al., 2014 | |
| CRISPR3-atad5b | Shin et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | ATPase, AAA-type, core | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|
| UniProtKB:A0A8M1NDC2 | InterPro | 1063 | |||
| UniProtKB:A0A0R4IQJ5 | InterPro | 1060 | |||
| UniProtKB:Q6PFI7 | InterPro | 1060 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
atad5b-201
(1)
|
Ensembl | 429 nt | ||
| mRNA |
atad5b-202
(1)
|
Ensembl | 3,932 nt | ||
| mRNA |
atad5b-203
(1)
|
Ensembl | 7,192 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-10P5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66453 | ZFIN Curated Data | |
| Has Artifact | EST | fb23b03 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001082829 (1) | 3961 nt | ||
| Genomic | GenBank:AL954746 (1) | 231840 nt | ||
| Polypeptide | UniProtKB:A0A8M1NDC2 (1) | 1063 aa |
- Shin, U., Nakhro, K., Oh, C.K., Carrington, B., Song, H., Varshney, G.K., Kim, Y., Song, H., Jeon, S., Robbins, G., Kim, S., Yoon, S., Choi, Y.J., Kim, Y.J., Burgess, S., Kang, S., Sood, R., Lee, Y., Myung, K. (2021) Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. DNA repair. 107:103173
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Lai, Y., Liang, M., Hu, ., Zeng, Z., Lin, H., Yi, G., Li, M., Liu, Z. (2018) RNF135 is a positive regulator of IFN expression and involved in RIG-I signaling pathway by targeting RIG-I. Fish & shellfish immunology. 86:474-479
- Thomas, H.R., Percival, S.M., Yoder, B.K., Parant, J.M. (2014) High-Throughput Genome Editing and Phenotyping Facilitated by High Resolution Melting Curve Analysis. PLoS One. 9:e114632
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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