Gene
cenpt
- ID
- ZDB-GENE-030131-3256
- Name
- centromere protein T
- Symbol
- cenpt Nomenclature History
- Previous Names
-
- fc31h11
- fc75c05
- si:ch211-225g23.1
- wu:fc31h11 (1)
- wu:fc75c05
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be involved in chromosome segregation and mitotic cell cycle. Predicted to act upstream of or within kinetochore assembly. Predicted to be located in kinetochore and nucleus. Used to study Seckel syndrome. Orthologous to human CENPT (centromere protein T).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Babu et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Hung et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-cenpt | N/A | Hung et al., 2017 |
| MO2-cenpt | N/A | Hung et al., 2017 |
| MO3-cenpt | N/A | Hung et al., 2017 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Short stature and microcephaly with genital anomalies | 618702 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Seckel syndrome | WT + MO3-cenpt | standard conditions | Hung et al., 2017 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CENP-T/Histone H4, histone fold | Centromere protein T | Histone-fold |
|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z3Y5 | InterPro | 901 | |||
| UniProtKB:E9QIT3 | InterPro | 914 | |||
| UniProtKB:A0A8M6YX66 | InterPro | 919 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:ch211-225g23.1-201
(1)
|
Ensembl | 3,125 nt | ||
| mRNA |
si:ch211-225g23.1-202
(1)
|
Ensembl | 543 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-225G23 | ZFIN Curated Data | |
| Contains | SNP | rs3729069 | ZFIN Curated Data | |
| Contains | SNP | rs3729070 | ZFIN Curated Data | |
| Contains | SNP | rs3729071 | ZFIN Curated Data | |
| Contains | SNP | rs3729072 | ZFIN Curated Data | |
| Contains | SNP | rs3729073 | ZFIN Curated Data | |
| Contains | SNP | rs3729074 | ZFIN Curated Data | |
| Contains | SNP | rs3729075 | ZFIN Curated Data | |
| Contains | SNP | rs3729076 | ZFIN Curated Data | |
| Encodes | EST | fc31h11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_017353029 (1) | 3060 nt | ||
| Genomic | GenBank:AL928952 (2) | 146502 nt | ||
| Polypeptide | UniProtKB:A0A8M6YX66 (1) | 919 aa |
- Comparative Orthology
- Alliance
- Babu, S., Takeuchi, Y., Masai, I. (2022) Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina. eLIFE. 11
- Hung, C.Y., Volkmar, B., Baker, J.D., Bauer, J.W., Gussoni, E., Hainzl, S., Klausegger, A., Lorenzo, J., Mihalek, I., Rittinger, O., Tekin, M., Dallman, J.E., Bodamer, O.A. (2017) A defect in the inner kinetochore protein CENPT causes a new syndrome of severe growth failure. PLoS One. 12:e0189324
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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