Gene
pabpc1a
- ID
- ZDB-GENE-030131-3238
- Name
- poly(A) binding protein, cytoplasmic 1a
- Symbol
- pabpc1a Nomenclature History
- Previous Names
-
- pabpc1
- wu:fb16a02
- wu:fc31e01
- wu:fi19b08
- wu:fj12d09
- wu:fj61f06
- zgc:109879
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Acts upstream of or within heart development. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in several structures, including blastodisc; digestive system; eye; pectoral fin bud; and ventral mesenchyme. Orthologous to several human genes including PABPC1 (poly(A) binding protein cytoplasmic 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7151399 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi3202bTg | Transgenic insertion | Exon 1 | Unknown | DNA | |
| la027788Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa39135 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 3 of 3
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-pabpc1a | N/A | (2) |
| MO2-pabpc1a | N/A | Yang et al., 2019 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR002004 | Polyadenylate-binding protein/Hyperplastic disc protein, C-terminal |
| Domain | IPR003954 | RNA recognition motif domain, eukaryotes |
| Domain | IPR034364 | PABP, RNA recognition motif 1 |
| Domain | IPR045305 | PABP, RNA recognition motif 2 |
| Family | IPR006515 | Polyadenylate binding protein, human types 1, 2, 3, 4 |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
| Homologous_superfamily | IPR036053 | PABC (PABP) domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleotide-binding alpha-beta plait domain superfamily | PABC (PABP) domain | PABP, RNA recognition motif 1 | PABP, RNA recognition motif 2 | Polyadenylate binding protein, human types 1, 2, 3, 4 | Polyadenylate-binding protein/Hyperplastic disc protein, C-terminal | RNA-binding domain superfamily | RNA recognition motif domain | RNA recognition motif domain, eukaryotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QB54 | InterPro | 634 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pabpc1a-201
(1)
|
Ensembl | 2,554 nt | ||
| mRNA |
pabpc1a-202
(1)
|
Ensembl | 2,033 nt | ||
| ncRNA |
pabpc1a-003
(1)
|
Ensembl | 539 nt | ||
| ncRNA |
pabpc1a-004
(1)
|
Ensembl | 660 nt | ||
| ncRNA |
pabpc1a-005
(1)
|
Ensembl | 330 nt | ||
| ncRNA |
pabpc1a-006
(1)
|
Ensembl | 747 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001031676 (1) | 2412 nt | ||
| Genomic | GenBank:CU855877 (2) | 30279 nt | ||
| Polypeptide | UniProtKB:F1QB54 (1) | 634 aa |
- Fouchécourt, S., Picolo, F., Elis, S., Lécureuil, C., Thélie, A., Govoroun, M., Brégeon, M., Papillier, P., Lareyre, J.J., Monget, P. (2019) An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. BMC Evolutionary Biology. 19:137
- König, D., Jaźwińska, A. (2019) Zebrafish fin regeneration involves transient serotonin synthesis. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 27(4):375-385
- Yang, Y., Wang, L., Han, X., Yang, W.L., Zhang, M., Ma, H.L., Sun, B.F., Li, A., Xia, J., Chen, J., Heng, J., Wu, B., Chen, Y.S., Xu, J.W., Yang, X., Yao, H., Sun, J., Lyu, C., Wang, H.L., Huang, Y., Sun, Y.P., Zhao, Y.L., Meng, A., Ma, J., Liu, F., Yang, Y.G. (2019) RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Molecular Cell. 75(6):1188-1202.e11
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Hosono, Y., Niknafs, Y.S., Prensner, J.R., Iyer, M.K., Dhanasekaran, S.M., Mehra, R., Pitchiaya, S., Tien, J., Escara-Wilke, J., Poliakov, A., Chu, S.C., Saleh, S., Sankar, K., Su, F., Guo, S., Qiao, Y., Freier, S.M., Bui, H.H., Cao, X., Malik, R., Johnson, T.M., Beer, D.G., Feng, F.Y., Zhou, W., Chinnaiyan, A.M. (2017) Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA. Cell. 171:1559-1572.e20
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Flamand, M.N., Wu, E., Vashisht, A., Jannot, G., Keiper, B.D., Simard, M.J., Wohlschlegel, J., Duchaine, T.F. (2016) Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans. Nucleic acids research. 44(12):5924-35
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Tseng, L.C., Zhang, C., Cheng, C.M., Xu, H., Hsu, C.H., Jiang, Y.J. (2014) New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens. PLoS One. 9:e93394
- Carlson, P., Smalley, D.M., and Van Beneden, R.J. (2013) Proteomic analysis of arsenic-exposed zebrafish (Danio rerio) identifies altered expression in proteins involved in fibrosis and lipid uptake in a gender-specific manner. Toxicological sciences : an official journal of the Society of Toxicology. 134(1):83-91
1 - 10 of 21
Show