Gene
dhodh
- ID
- ZDB-GENE-030131-3157
- Name
- dihydroorotate dehydrogenase
- Symbol
- dhodh Nomenclature History
- Previous Names
-
- wu:fc29a01
- zgc:103492
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have dihydroorotate dehydrogenase activity. Predicted to be involved in 'de novo' pyrimidine nucleobase biosynthetic process and pyrimidine ribonucleotide biosynthetic process. Predicted to localize to mitochondrial inner membrane. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103492 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| postaxial acrofacial dysostosis | Alliance | Miller syndrome | 263750 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001295 | Dihydroorotate dehydrogenase, conserved site |
| Domain | IPR005720 | Dihydroorotate dehydrogenase, catalytic |
| Family | IPR005719 | Dihydroorotate dehydrogenase, class 2 |
| Family | IPR050074 | Dihydroorotate dehydrogenase |
| Homologous_superfamily | IPR013785 | Aldolase-type TIM barrel |
Domain Details Per Protein
| Protein | Length | Aldolase-type TIM barrel | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase, catalytic | Dihydroorotate dehydrogenase, class 2 | Dihydroorotate dehydrogenase, conserved site |
|---|---|---|---|---|---|---|
|
UniProtKB:Q5PR57
|
407 | |||||
|
UniProtKB:A0A8M2BE38
|
406 |
Interactions and Pathways
No data available
Plasmids
No data available