Gene

dpysl5a

ID

ZDB-GENE-030131-3136

Name

dihydropyrimidinase like 5a

Symbol

dpysl5a Nomenclature History

Previous Names

CRMP-5a (1)
fc28b06
im:7146614
wu:fc28b06

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. Predicted to act upstream of or within axon guidance. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in nervous system; spinal cord neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome. Orthologous to human DPYSL5 (dihydropyrimidinase like 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7146614 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dpysl5a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Ritscher-Schinzel syndrome 4	619435

Associated With dpysl5a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006680	Amidohydrolase-related
Family	IPR011778	Hydantoinase/dihydropyrimidinase
Family	IPR050378	Metallo-dependent Hydrolases Superfamily
Homologous_superfamily	IPR011059	Metal-dependent hydrolase, composite domain superfamily
Homologous_superfamily	IPR032466	Metal-dependent hydrolase

Domain Details Per Protein

Protein	Length	Amidohydrolase-related	Hydantoinase/dihydropyrimidinase	Metal-dependent hydrolase	Metal-dependent hydrolase, composite domain superfamily	Metallo-dependent Hydrolases Superfamily
UniProtKB:Q52PJ7 InterPro	564

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dpysl5a-201 (1) Ensembl	Ensembl	4,408 nt	Select Tool ZFIN BLAST
mRNA	dpysl5a-202 (1) Ensembl	Ensembl	3,509 nt	Select Tool ZFIN BLAST
mRNA	dpysl5a-203 (1) Ensembl	Ensembl	1,715 nt	Select Tool ZFIN BLAST
mRNA	dpysl5a-204 (1) Ensembl	Ensembl	4,486 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations