Gene

cyp3c1

ID

ZDB-GENE-030131-3060

Name

cytochrome P450, family 3, subfamily c, polypeptide 1

Symbol

cyp3c1 Nomenclature History

Previous Names

CYP3A (1)
wu:fa96d12
wu:fc26b04
zgc:56626

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Enables heme binding activity. Predicted to be located in membrane. Is expressed in several structures, including digestive system; heart; integument; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A4 (cytochrome P450 family 3 subfamily A member 4); and CYP3A43 (cytochrome P450 family 3 subfamily A member 43).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56626 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cyp3c1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Vitamin D-dependent rickets, type 3	619073

Associated With cyp3c1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017972	Cytochrome P450, conserved site
Family	IPR001128	Cytochrome P450
Family	IPR002401	Cytochrome P450, E-class, group I
Family	IPR050705	Cytochrome P450 3A
Homologous_superfamily	IPR036396	Cytochrome P450 superfamily

Domain Details Per Protein

Protein	Length	Cytochrome P450	Cytochrome P450 3A	Cytochrome P450, conserved site	Cytochrome P450, E-class, group I	Cytochrome P450 superfamily
UniProtKB:Q7ZTW6 InterPro	505

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cyp3c1-201 (1) Ensembl	Ensembl	1,931 nt	Select Tool ZFIN BLAST
mRNA	cyp3c1-202 (1) Ensembl	Ensembl	617 nt	Select Tool ZFIN BLAST
mRNA	cyp3c1-203 (1) Ensembl	Ensembl	530 nt	Select Tool ZFIN BLAST
mRNA	cyp3c1-204 (1) Ensembl	Ensembl	1,741 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations