Gene
cyp3c1
- ID
- ZDB-GENE-030131-3060
- Name
- cytochrome P450, family 3, subfamily c, polypeptide 1
- Symbol
- cyp3c1 Nomenclature History
- Previous Names
-
- CYP3A (1)
- wu:fa96d12
- wu:fc26b04
- zgc:56626
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables heme binding activity. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including digestive system; heart; integument; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A4 (cytochrome P450 family 3 subfamily A member 4); and CYP3A43 (cytochrome P450 family 3 subfamily A member 43).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56626 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Vitamin D-dependent rickets, type 3 | 619073 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450 3A | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZTW6 | InterPro | 505 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp3c1-201
(1)
|
Ensembl | 1,931 nt | ||
| mRNA |
cyp3c1-202
(1)
|
Ensembl | 617 nt | ||
| mRNA |
cyp3c1-203
(1)
|
Ensembl | 530 nt | ||
| mRNA |
cyp3c1-204
(1)
|
Ensembl | 1,741 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-21N8 | Corley-Smith et al., 2006 | |
| Encodes | EST | fa96d12 | ZFIN Curated Data | |
| Encodes | EST | fc26b04 | ||
| Encodes | cDNA | MGC:56626 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212673 (1) | 1899 nt | ||
| Genomic | GenBank:BX649536 (1) | 203180 nt | ||
| Polypeptide | UniProtKB:Q7ZTW6 (1) | 505 aa |
- Zhao, X., Huang, X., Peng, W., Han, M., Zhang, X., Zhu, K., Shao, B. (2022) Chlorine disinfection byproduct of diazepam affects nervous system function and possesses gender-related difference in zebrafish. Ecotoxicology and environmental safety. 238:113568
- Duan, X.Y., Ma, R.J., Hsiao, C.D., Jiang, Z.Z., Zhang, L.Y., Zhang, Y., Liu, K.C. (2021) Tripterygium wilfordii multiglycoside-induced hepatotoxicity via inflammation and apoptosis in zebrafish. Chinese Journal of Natural Medicines. 19:750-757
- Nawaji, T., Yamashita, N., Umeda, H., Zhang, S., Mizoguchi, N., Seki, M., Kitazawa, T., Teraoka, H. (2020) Cytochrome P450 Expression and Chemical Metabolic Activity before Full Liver Development in Zebrafish. Pharmaceuticals (Basel, Switzerland). 13(12):
- Teng, M., Wang, C., Song, M., Chen, X., Zhang, J., Wang, C. (2020) Chronic exposure of zebrafish (Danio rerio) to flutolanil leads to endocrine disruption and reproductive disorders. Environmental research. 184:109310
- Wang, J., Jia, B., Li, Y., Ren, B., Liang, H., Yan, D., Xie, H., Zhang, X., Liang, H. (2020) Effects of multi-walled carbon nanotubes on the enantioselective toxicity of the chiral insecticide indoxacarb toward zebrafish (Danio rerio). Journal of hazardous materials. 397:122724
- Kubota, A., Kawai, Y.K., Yamashita, N., Lee, J.S., Kondoh, D., Zhang, S., Nishi, Y., Suzuki, K., Kitazawa, T., Teraoka, H. (2019) Transcriptional profiling of cytochrome P450 genes in the liver of adult zebrafish, Danio rerio. The Journal of Toxicological Sciences. 44:347-356
- Teng, M., Chen, X., Wang, C., Song, M., Zhang, J., Bi, S., Wang, C. (2019) Life cycle exposure to propiconazole reduces fecundity by disrupting the steroidogenic pathway and altering DNA methylation in zebrafish (Danio rerio). Environment International. 135:105384
- Huang, P., Xiong, S., Kang, J., Mei, J., Gui, J.F. (2018) Stat5b Regulates Sexually Dimorphic Gene Expression in Zebrafish Liver.. Frontiers in Physiology. 9:676
- Shaya, L., Jones, D.E., Wilson, J.Y. (2018) CYP3C gene regulation by the aryl hydrocarbon and estrogen receptors in zebrafish. Toxicology and applied pharmacology. 362:77-85
- Verbueken, E., Bars, C., Ball, J.S., Periz-Stanacev, J., Marei, W.F.A., Tochwin, A., Gabriëls, I.J., Michiels, E.D.G., Stinckens, E., Vergauwen, L., Knapen, D., Van Ginneken, C.J., Van Cruchten, S.J. (2018) From mRNA Expression of Drug Disposition Genes to In Vivo Assessment of CYP-Mediated Biotransformation during Zebrafish Embryonic and Larval Development. International Journal of Molecular Sciences. 19(12)
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