Gene
ercc3
- ID
- ZDB-GENE-030131-3043
- Name
- excision repair cross-complementation group 3
- Symbol
- ercc3 Nomenclature History
- Previous Names
-
- wu:fc25f08
- xpb (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable 3'-5' DNA helicase activity. Predicted to be involved in DNA metabolic process; apoptotic process; and transcription initiation at RNA polymerase II promoter. Predicted to act upstream of or within nucleotide-excision repair. Predicted to be located in nucleus. Predicted to be part of nucleotide-excision repair factor 3 complex; transcription factor TFIIH holo complex; and transcription preinitiation complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; photosensitive trichothiodystrophy 2; trichothiodystrophy; xeroderma pigmentosum; and xeroderma pigmentosum group B. Orthologous to human ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55607 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| photosensitive trichothiodystrophy 2 | Alliance | Trichothiodystrophy 2, photosensitive | 616390 |
| xeroderma pigmentosum group B | Alliance | Xeroderma pigmentosum, group B | 610651 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR006935 | Helicase/UvrB, N-terminal |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR032438 | ERCC3/RAD25/XPB helicase, C-terminal domain |
| Domain | IPR032830 | Helicase XPB/Ssl2, N-terminal domain |
| Family | IPR001161 | Helicase XPB/Ssl2 |
| Family | IPR050615 | ATP-dependent DNA Helicase |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | ATP-dependent DNA Helicase | ERCC3/RAD25/XPB helicase, C-terminal domain | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | Helicase/UvrB, N-terminal | Helicase XPB/Ssl2 | Helicase XPB/Ssl2, N-terminal domain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZVV1
|
782 | ||||||||
|
UniProtKB:B2GSW0
|
782 |
Interactions and Pathways
No data available
Plasmids
No data available