Gene

psmc6

ID

ZDB-GENE-030131-304

Name

proteasome 26S subunit, ATPase 6

Symbol

psmc6 Nomenclature History

Previous Names

fb20g04
wu:fb20g04
wu:fc85c10

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to enable proteasome-activating activity. Predicted to be involved in ERAD pathway; positive regulation of RNA polymerase II transcription preinitiation complex assembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be part of proteasome regulatory particle, base subcomplex. Used to study fetal alcohol spectrum disorder. Orthologous to human PSMC6 (proteasome 26S subunit, ATPase 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:101799 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With psmc6 Human Ortholog

No data available

Associated With psmc6 Via Experimental Models

Human Disease	Fish	Conditions	Citations
fetal alcohol spectrum disorder	psmc6^{hi3593Tg/hi3593Tg}	standard conditions	Weeks et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003960	ATPase, AAA-type, conserved site
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR032501	Proteasomal ATPase, second OB domain
Domain	IPR041569	AAA ATPase, AAA+ lid domain
Family	IPR050221	26S Proteasome Regulatory ATPase
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Additional Resources	Length	26S Proteasome Regulatory ATPase	AAA ATPase, AAA+ lid domain	AAA+ ATPase domain	ATPase, AAA-type, conserved site	ATPase, AAA-type, core	Nucleic acid-binding, OB-fold	P-loop containing nucleoside triphosphate hydrolase	Proteasomal ATPase, second OB domain
UniProtKB:Q6DRD2	InterPro	389

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
aberrant processed transcript	psmc6-202 (1) Ensembl	Ensembl		834 nt	Select Tool ZFIN BLAST
mRNA	psmc6-201 (1) Ensembl	Ensembl		1,561 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations