Gene

stub1

ID

ZDB-GENE-030131-2963

Name

STIP1 homology and U-Box containing protein 1

Symbol

stub1 Nomenclature History

Previous Names

CHIP (1)
wu:fc22f04
zgc:56076

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 16 and cerebellar ataxia type 48. Orthologous to human STUB1 (STIP1 homology and U-box containing protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:56076 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With stub1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive spinocerebellar ataxia 16	Alliance	Spinocerebellar ataxia, autosomal recessive 16	615768
cerebellar ataxia type 48	Alliance	Spinocerebellar ataxia 48	618093

Associated With stub1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003613	U-box domain
Domain	IPR041312	CHIP, N-terminal tetratricopeptide repeat domain
Domain	IPR045202	CHIP , U-box domain
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Repeat	IPR019734	Tetratricopeptide repeat

Domain Details Per Protein

Protein	Length	CHIP, N-terminal tetratricopeptide repeat domain	CHIP , U-box domain	Tetratricopeptide-like helical domain superfamily	Tetratricopeptide repeat	U-box domain	Zinc finger, RING/FYVE/PHD-type
UniProtKB:F6NGW2 InterPro PDB	284
UniProtKB:A0A8M9P5S7 InterPro	291
UniProtKB:F1Q8K3 InterPro	287

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	stub1-202 (1) Ensembl	Havana	539 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	stub1-203 (1) Ensembl	Havana	1514 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	stub1-204 (1) Ensembl	Havana	807 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations