Gene

stub1

ID
ZDB-GENE-030131-2963
Name
STIP1 homology and U-Box containing protein 1
Symbol
stub1 Nomenclature History
Previous Names
  • CHIP (1)
  • wu:fc22f04
  • zgc:56076
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to have several functions, including TPR domain binding activity; chaperone binding activity; and heat shock protein binding activity. Predicted to be involved in several processes, including cellular response to misfolded protein; positive regulation of cellular protein metabolic process; and proteolysis involved in cellular protein catabolic process. Predicted to localize to Z disc. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 16 and cerebellar ataxia type 48. Orthologous to human STUB1 (STIP1 homology and U-box containing protein 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With stub1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive spinocerebellar ataxia 16 Alliance Spinocerebellar ataxia, autosomal recessive 16 615768
cerebellar ataxia type 48 Alliance ?Spinocerebellar ataxia 48 618093
Associated With stub1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003613 U box domain
Domain IPR013026 Tetratricopeptide repeat-containing domain
Domain IPR041312 CHIP, N-terminal tetratricopeptide repeat domain
Homologous_superfamily IPR011990 Tetratricopeptide-like helical domain superfamily
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Repeat IPR019734 Tetratricopeptide repeat
Domain Details Per Protein
Protein Length CHIP, N-terminal tetratricopeptide repeat domain Tetratricopeptide-like helical domain superfamily Tetratricopeptide repeat Tetratricopeptide repeat-containing domain U box domain Zinc finger, RING/FYVE/PHD-type
UniProtKB:E9QDW8 161
UniProtKB:F1Q8K3 287
UniProtKB:E9QEY7 74
UniProtKB:Q7ZTZ6 284
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations