Gene

nampt2

ID

ZDB-GENE-030131-2931

Name

nicotinamide phosphoribosyltransferase 2

Symbol

nampt2 Nomenclature History

Previous Names

namptb (1)
im:7051384
wu:fc21g12
wu:fc27h03
wu:fd15d03
zgc:55764

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have cytokine activity; nicotinamide phosphoribosyltransferase activity; and nicotinate-nucleotide diphosphorylase (carboxylating) activity. Predicted to be involved in NAD biosynthetic process and circadian regulation of gene expression. Predicted to localize to cytoplasm; extracellular space; and nucleus. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human NAMPT (nicotinamide phosphoribosyltransferase).

Genome Resources

Note

This gene name was updated because the phylogenetic tree indicates this was the result of a duplication event PRIOR to the divergence of ray- and lobe-fin fishes and not the teleost WGD

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55764 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nampt2 Human Ortholog

No data available

Associated With nampt2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR041525	Nicotinate/nicotinamide phosphoribosyltransferase
Domain	IPR041529	Nicotinamide phosphoribosyltransferase, N-terminal domain
Family	IPR016471	Nicotinamide phosphoribosyl transferase
Homologous_superfamily	IPR013785	Aldolase-type TIM barrel
Homologous_superfamily	IPR036068	Nicotinate phosphoribosyltransferase-like, C-terminal