Gene
lpgat1
- ID
- ZDB-GENE-030131-2906
- Name
- lysophosphatidylglycerol acyltransferase 1
- Symbol
- lpgat1 Nomenclature History
- Previous Names
-
- fc21c12
- fj66b10
- si:dkey-30h14.2
- wu:fc21c12
- wu:fj66b10 (1)
- zgc:112278
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in testis. Orthologous to human LPGAT1 (lysophosphatidylglycerol acyltransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Shibata et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Shibata et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-lpgat1 | Shibata et al., 2022 | |
| CRISPR2-lpgat1 | Shibata et al., 2022 | |
| MO1-lpgat1 | N/A | Shibata et al., 2022 |
| MO2-lpgat1 | N/A | Shibata et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Acyltransferase, C-terminal domain | Phospholipid/glycerol acyltransferase |
|---|---|---|---|---|
| UniProtKB:Q4KMD5 | InterPro | 371 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lpgat1-201
(1)
|
Ensembl | 3,179 nt | ||
| mRNA |
lpgat1-202
(1)
|
Ensembl | 3,529 nt | ||
| mRNA |
lpgat1-203
(1)
|
Ensembl | 373 nt | ||
| mRNA |
lpgat1-204
(1)
|
Ensembl | 802 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-30H14 | ||
| Encodes | EST | fc21c12 | ||
| Encodes | EST | fj66b10 | ||
| Encodes | cDNA | MGC:112278 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001029958 (1) | 3196 nt | ||
| Genomic | GenBank:BX248403 (1) | 154669 nt | ||
| Polypeptide | UniProtKB:Q4KMD5 (1) | 371 aa |
- Shibata, T., Kawana, H., Nishino, Y., Ito, Y., Sato, H., Onishi, H., Kano, K., Inoue, A., Taketomi, Y., Murakami, M., Kofuji, S., Nishina, H., Miyazawa, A., Kono, N., Aoki, J. (2022) Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish. Scientific Reports. 12:7312
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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