Gene

polr3b

ID
ZDB-GENE-030131-2887
Name
polymerase (RNA) III (DNA directed) polypeptide B
Symbol
polr3b Nomenclature History
Previous Names
  • slj
  • si:dkey-103i16.3
  • slim jim
  • wu:fc20h06
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to contribute to RNA polymerase III activity. Involved in digestive tract development; exocrine pancreas development; and tRNA transcription. Predicted to localize to RNA polymerase III complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadism. Is expressed in intestine; liver; nervous system; and retina. Orthologous to human POLR3B (RNA polymerase III subunit B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Yee et al., 2007
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With polr3b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadism Alliance Leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism 614381
Charcot-Marie-Tooth disease, demyelinating, type 1I 619742
Associated With polr3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR007121 RNA polymerase, beta subunit, conserved site
Domain IPR007120 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain
Domain IPR007641 RNA polymerase Rpb2, domain 7
Domain IPR007642 RNA polymerase Rpb2, domain 2
Domain IPR007644 RNA polymerase, beta subunit, protrusion
Domain IPR007645 RNA polymerase Rpb2, domain 3
Domain IPR007646 RNA polymerase Rpb2, domain 4
Domain IPR007647 RNA polymerase Rpb2, domain 5
Family IPR015712 DNA-directed RNA polymerase, subunit 2
Homologous_superfamily IPR014724 RNA polymerase Rpb2, OB-fold
Homologous_superfamily IPR037033 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily
Domain Details Per Protein
Protein Length DNA-directed RNA polymerase, subunit 2 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily RNA polymerase, beta subunit, conserved site RNA polymerase, beta subunit, protrusion RNA polymerase Rpb2, domain 2 RNA polymerase Rpb2, domain 3 RNA polymerase Rpb2, domain 4 RNA polymerase Rpb2, domain 5 RNA polymerase Rpb2, domain 7 RNA polymerase Rpb2, OB-fold
UniProtKB:F1QQA2 1130
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations